应用牵张成骨技术(DO)整复腭裂实验动物模型的建立  

Distraction osteogenesis for correction of cleft palate: establishment of the experimental animal model

作　　者：张浚睿[1] 封兴华[1] 魏建华[1] 

机构地区：[1]第四军医大学口腔医学院颌面外科,陕西省西安市710032

出　　处：《中国美容医学》2003年第2期173-175,T006,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:建立长期、稳定的腭裂动物模型,并可用于以DO成骨方式进行畸形矫治。方法:1-1.5岁杂种犬7只为实验对象,其中以2只为实验对照组,以外科手术形成硬腭部8mm×30mm全层洞穿缺损裂隙。8周后观察裂隙软、硬组织形态。5只为实验组,在形成模型的同时放置固定DO装置,并形成骨转移盘,观察模型建立后牵张成骨的可行性。结果:实验犬手术后均成活、健康状况良好,实验对照组犬8周后上腭裂隙仍存在,干骨标本见骨缺损大小形状与手术时无差别,实验组犬安置DO装置后伤口愈合良好,DO装置固定牢靠。结论:通过手术方式建立的腭裂动物模型,经长期观察裂隙不能自行修复,安置DO装置后效果稳定。腭裂DO装置设计较合理,建立的DO矫正腭裂模型具有充分的可行性。Objective: To establish an animal model of experimental cleft palate for DO treatment. Methods: 7 healthy dogs (age 1-1.5years) were assigned randomly to 2 groups. The experimental group contained 5 dogs that underwent 8mm×30mm palatal osteoectomy and DO procedure. The other 2 dogs were performed palate osteoectomy only as the experimental control with euthanasia in 8 weeks. The cleft of the control was measured and compared with the data when the operation was done.the state of the cleft and the stability of the DO apparatus were also observed in the experimental group. Results: All dogs were in good condition within the experiment period. The shape and width of the cleft palate kept almost the same as when it was made on control dogs. In experimental group, the wound healed in 7-10 days. The DO apparatus were stable. Conclusions: It is a sound way of establishing experimental cleft palate on dogs by surgical operation for DO treatment use.

关 键 词：牵张成骨技术 腭裂 动物模型 可行性 

分 类 号：R782.22[医药卫生—口腔医学]