慢性肝病患者血卟啉变化初探  

Preliminary Investigation into Changes of Hematoporphyrin in Patients with Chronic Hepatopathy

作　　者：刘桪[1] 李少华[1] 高善玲[1] 刘振中[2] 陈丽娜[3] 谢文章[3] 许艳[3] 马波[3] 李冰 

机构地区：[1]哈尔滨医科大学二院消化内科 [2]巴彦县人民医院内科 [3]哈尔滨医科大学生物物理学教研室 [4]703研究所医院

出　　处：《哈尔滨医科大学学报》1992年第2期99-101,共3页Journal of Harbin Medical University

摘　　要：本文利用光致发光荧光光谱技术,测定94例慢性肝病和32侧健康对照组的血卟啉。结果表明锌卟啉和原卟啉峰,慢性肝病组都明显高于对照组(P<0.01)。静止性肝病患者中原卟啉的检出率也在62%以上,其敏感性高于常规肝功检查,对判定肝损害程度有较大的临床意义。Hematoporphyrin was determined by fluorescence spectroscopy in 94 cases of chronic hepatopathy and in 32 normal controls. The result showed that both the peak value of zinic porphyrin and of protoporphyrin in patients with chronic hepatopathy were much higher than that of controls (P<0.01). These two values in patients with active hepatopathy were higher than those with static hepatopathy, especially the peak value of protoporphyrin(P<0.05). It was lower in the patients with hepatic encephalopathy. Detectable rate of protoporphyrin even in the patients with static hepatopathy was over 62%. Its sensitivity was higher than that routine method of liver functional test, Therefore the method has notable clinical significance to determine the degree of lesion in the liver.

关 键 词：血卟啉 荧光光谱 肝疾病 

分 类 号：R575.02[医药卫生—消化系统]