大肠癌患者血清胃泌素与癌组织的核仁组成区嗜银染色计数的关系──附56例检测报告  

Relationship between serum gastrin level and the count of argyrophilia nucleolar organiser regions in patients with large intestine cancer.

作　　者：李根武[1] 周宇[1] 王菊岩[2] 朱艺[3] 

机构地区：[1]广东医学院附属医院消化内科,524001 [2]广东医学院附属医院内镜中心,524001 [3]海南省人民医院外科,570311

出　　处：《新医学》2003年第4期219-220,223,共3页Journal of New Medicine

摘　　要：研究大肠癌患者血清胃泌素水平的变化和癌组织的核仁组成区嗜银染色(argyrophilianucleolarorganiserregions,AgNORs)计数的关系。方法:用放射免疫法测定56例大肠癌患者及20名正常人的血清胃泌素水平并作比较;用胶质银染技术检测56例病人癌组织中AgNORs计数,分析大肠癌患者血清胃泌素水平与癌组织中的AgNORs计数的相关关系。结果:大肠癌组术前血清胃泌素水平犤(123±32)ng/L犦明显高于正常对照组犤(87±29)ng/L犦,P<0.05;术前Duke分期为C期的患者血清胃泌素水平犤(135±38)ng/L犦明显高于A期患者犤(102±37)ng/L犦,P<0.05;术后生存期不足5年的患者血清胃泌素水平犤(134±31)ng/L犦明显高于生存期达5年的患者犤(104±32)ng/L犦,P<0.05。大肠癌患者术前的血清胃泌素水平升高与癌组织的AgNORs计数呈正相关(r=0.52,P<0.05),术后生存期不足5年的患者AgNORs计数犤(9.8±2.1)颗粒/细胞犦明显高于生存期达5年的患者犤(7.2±1.1)颗粒/细胞犦。结论:大肠癌患者血清胃泌素水平与癌组织的AgNORs计数有一定的相关性,术前血清胃泌素水平可作为预测大肠癌预后的评价指标之一。Objective:To study the relationship between the change of serum gastrin level and the count of argyrophilia nucleolar organiser regions (AgNORs) in patients with large intestine cancer. Methods:Serum gastrin level in 56 cases with large intestine cancer and in 20 normal subjects were determined by radioimmunological assay and AgNORs in the carcinoma tissues was counted by colloid argentaffin stain technique. The relationship between serum gastrin level in patients with large intestine cancer and the count of AgNORs in the carcinoma tissues was analyzed.Results:Preoperative serum gastein levels in the group of patients with large intestine cancer were significantly higher than that in the control group[(123±32) ng/L vs (87±29) ng/L],P<0.05. Preoperative serum gastrin levels in patients with C stage of Duke staging were significantly higher than that in those with A stage [(135±38) ng/L vs (102±37) ng/L],P<0.05. Serum gastrin levels in patients with survival time less than 5 years were significantly higher than those over 5 years [(134±31) ng/L vs (104±32) ng/L],P<0.05. Preoperative serum gastrin levels in the group of patients with large intestine cancer were positively correlated with the count of AgNORs in the carcinoma tissues (r=0.52,P<0.05). The count of AgNORs in the patients with survival time was less than 5 years was higher than those over 5 years[(9.8±2.1) vs (7.2±1.1)]. Conclusion:Serum gastrin levels in patients with large intestine cancer is correlated with the count of AgNORs in the carcinoma tissues. The detection of serum gastrin before operation can be use as a marker of prognosis for large intestine cancer.

关 键 词：大肠癌 患者 血清 胃泌素 癌组织 核仁组成区 

分 类 号：R735.34[医药卫生—肿瘤]