稀土钐离子与微过氧化物酶-11的相互作用初探  

Study on the Interaction between Samarium Ion and Microperoxidase-11

作　　者：李奚[1] 黄晓华[1] 姜慧君[2] 高颖[3] 陆天虹[1] 李邨[1] 

机构地区：[1]南京师范大学化学与环境科学学院,南京210097 [2]南京医科大学基础医学院,南京210029 [3]哈尔滨师范大学化学系,哈尔滨150080

出　　处：《无机化学学报》2003年第5期513-516,共4页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金资助项目(No.29973015;20243002);国家计委稀土专项基金资助项目(No.GJX01100626);江苏省科技厅高新技术基金资助项目(No.BG2001045);江苏省教育厅高校自然科学基金资助项目(No.01KJB150006;02KJB150004);黑龙江省自然科学基金资助项目(No.B2000

摘　　要：The interaction between Sm3+and MP 11 in the aqueous solution was investigated with cyclic voltammetry, UV Vis absorption spectrum and circular dichroism. It was found for the first time that Sm3+could bond to O of carboxyl group in the heme group altering the surface charge of MP 11 molecule and thus increasing its diffusion coefficient.In addition, the interaction between Sm3+and MP 11 molecule would change the secondary structure of the MP 11 molecule increasing the exposure extent of the heme group in the MP 11 molecule.The above results could increase the reversibility of the electrochemical reaction of MP 11.The interaction between Sm3+and MP 11 in the aqueous solution was investigated with cyclic voltammetry, UV Vis absorption spectrum and circular dichroism. It was found for the first time that Sm3+could bond to O of carboxyl group in the heme group altering the surface charge of MP 11 molecule and thus increasing its diffusion coefficient.In addition, the interaction between Sm3+and MP 11 molecule would change the secondary structure of the MP 11 molecule increasing the exposure extent of the heme group in the MP 11 molecule.The above results could increase the reversibility of the electrochemical reaction of MP 11.

关 键 词：稀土离子 微过氧化物酶-ll 相互作用 循环伏安法 药物研究 

分 类 号：R914[医药卫生—药物化学]