大蒜素治疗大鼠缺氧性肺动脉高压的研究  

Study of Garlicin on Rat Hypoxic Pulmonary Hypertension

作　　者：陈学军[1] 薛占瑞[1] 河福金[1] 王玉清[1] 年丰[1] 

机构地区：[1]锦州医学院病理解剖学教研室,辽宁锦州121000

出　　处：《锦州医学院学报》2002年第6期14-15,共2页Journal of Jinzhou Medical College

摘　　要：观察大蒜素对腺泡内肺动脉高压 (PHT)是否具有阻抑效应 ,在常压缺氧条件下 ,选用 4 2只大鼠 ,分正常组、缺氧组和缺氧加大蒜素组 ,分别在 15天和 30天测右心室收缩压 ,并观察其变化。结果显示大蒜素能降低肺动脉压。从而提示大蒜素具有预防缺氧性肺动脉压升高的作用 。The inhibitory action of garlicin on remodeling of intra-acinar pulmonary arteries under pulmonary hypertension was studied.42 rats were fed in hypoxic environment under normal atmospheric pressure (10%O 2 10 hours/day)and divided into control group and hypoxia with garlicin group.On the 15th and 30th day of hypoxia,right ventricular systalic pressure was measured.Garlicin could decrease the pulmonary arteries pressure.Therefore,garlicin may play an important role in inhibiting pulmonary hypertpension.

关 键 词：大蒜素 肺动脉高压 大鼠 治疗 

分 类 号：R543.2[医药卫生—心血管疾病]