秋水仙碱对三叉神经痛治疗作用的实验研究  

Experimental study onthe therapeutic efficacy of colchicine ontrigeminal neuralgia

作　　者：张冰[1] 李晓刚[1] 郭福林[1] 高瑞驹[1] 尹晓东[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院口腔颌面外科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2003年第2期150-152,共3页Journal of Harbin Medical University

摘　　要：目的　观察大鼠眶下神经干注射秋水仙碱是否对三叉神经痛有治疗作用。方法　将一个 1mm2 的滤纸片(浸有 0 .2 %苦毒素 )直接放置于两侧延脑尾侧 1～ 2mm颈髓质表面至少 5min ,形成三叉神经痛模型。于右侧眶下神经干注射 0 .0 4 %秋水仙碱 2 0 0 μl。于用药后当日和第 2、5、6日分别记录实验侧与对照侧大鼠胫前肌肌电图 (EMG)。测量EMG波的振幅、时限、每次发作持续时间、开始出现发作的时间及至不发作的全程时间 ,并进行统计学对比分析。结果　实验侧术后第 2天较手术当日EMG振幅明显减小 ,术后第 5、6日EMG振幅虽有所回升 ,但与对照侧差别有显著意义 (P <0 .0 0 1)。结论　 0 .0 4Objective To observe whether colchicine could cure the trigeminal neuralgia. Methods The model of trigeminal neuralgia was formed by appling pricotoxin on the face of medulla. The drug was separately applied onto the each side of surface of the medulla to evoke the rat to scratch the ipsilateral face with hindlimb. Colchicine was injected into the right infraorbital nerve and the other side was infused nothing.The eletromyogram(EMG) of the anterior tibial muscle was recorded each side seperatedly at the 1,2,5 and 6 days. The EMG of one side was contrasted to another in order to analyze how the drug to affect the outbreak of the hyper-irritability. Results The experimental result showed that the change of amplitude of EMG was statistically significant( P <0.001)at the side of colchicine and at the control side no significant change( P >0.3)was observed. Conclusion The data indicate that colchicine could cure trigeminal neuralgia to a certain extent.

关 键 词：秋水仙碱 三叉神经痛 实验研究 治疗 

分 类 号：R745.110.5[医药卫生—神经病学与精神病学]