石胆草中两个新的苯乙醇苷类成分  

Two new phenylethanoid glycosides from Corallodiscus flabellata

作　　者：郑晓珂[1] 李军[1] 冯卫生[1] 毕跃峰[1] 冀春茹[1] 

机构地区：[1]河南中医学院,河南郑州450008

出　　处：《药学学报》2003年第4期268-271,共4页Acta Pharmaceutica Sinica

基　　金：河南省高校杰出科研人才创新工程资助项目(2 0 0 3KYCX0 0 2 );河南省杰出青年科学基金资助项目 (0 2 12 0 0 12 0 0 )

摘　　要：目的　研究石胆草 (Corallodiscusflabellata)的化学成分。方法　利用大孔吸附树脂、SephadexLH 2 0、硅胶柱色谱进行分离纯化 ,根据化合物的理化性质和光谱数据鉴定结构。结果　分离并鉴定了 5个化合物 ,分别为 3 ,4 二羟基苯乙醇 8 O [β D 芹糖基 (1→ 2 ) ] β D 葡糖苷 (I) ,3 ,4 二羟基苯乙醇 8 O [(5 O 香草酰基 ) β D 芹糖基 (1→2 ) ] β D 葡糖苷 (II) ,香草酸 (III) ,丁香酸 (IV) ,阿魏酸 (V)。 结论　I和II为新化合物 ,III。Aim To study the chemical constituents from Corallodiscus flabellata . Methods Fresh plant of Corallodiscus flabellata was extracted twice with boiling water, filtered to remove insoluble materials, concentrated under reduced pressure at temperature 55 ℃ to a small volume. The concentrated liquor was subjected to solvent solvent partitioning using ether, ethyl acetate, and n butanol (saturated with water). The fraction of ethyl acetate extract was chromatographed over macroporous adsorption resin (Diaion HP 20) eluted with a mixture of H 2O and MeOH in increasing MeOH content. Their fractions from resin were repeatedly chromatographed over Sephadex LH 20, Toyopearl HW 40, gel MCI, Gel CHP 20 and silica gel column. Structures of compounds obtained were identified on the basis of their spectral data, hydrolysis and chemical correlation. Results Two phenylethanoid glycosides (I, II) and three phenolic acids were obtained from the EtOAc fraction of water extracts. Their structures were identified as 3,4 dihydroxyphenylethanol 8 O [β D apiofuranosyl (1→2)] β D glucopyranoside (I), 3,4 dihydroxyphenylethanol 8 O [(5 O Vanilloyl) β D apiofuranosyl(1→2)] β D glucopyranoside (II), vanillic acid (III), syringic acid (IV) and ferulic acid (V). Conclusion I and II are new compounds. Compounds III, IV and V were isolated from this plant for the first time.

关 键 词：石胆草 苯乙醇苷 化学成分 大孔吸附树脂 分离纯化 硅胶柱色 

分 类 号：R914.4[医药卫生—药物化学]