曲唑酮和氟西汀治疗抑郁症疗效和副作用的对照研究  

A control study of Fluoxetine andTrazodone in the treatment of depressive episodes in clinic

作　　者：郑少雄[1] 杨权[1] 

机构地区：[1]汕头大学精神卫生中心,广东汕头515063

出　　处：《中国行为医学科学》2003年第2期157-158,共2页Chinese Journal of Behavioral Medical Science

摘　　要：目的　评估曲唑酮治疗抑郁症的效果和副作用。方法　应用曲唑酮和氟西汀治疗抑郁症 ,随机取样各 30例 ,并比较疗效和副作用 ,曲唑酮的初始剂量为 50mg d ,po ,3周内视病情需要增至 1 0 0～ 1 50mg d。氟西汀 2 0mg d ,疗程 4周。采用HAMD和SERS分别于用药前、治疗后第 7、1 4、2 1、2 8各评定一次。结果　曲唑酮与氟西汀疗效相仿 ,HAMD的平均分治疗前后差异有显著性 (P <0 .0 0 1 )。以HAMD减分 50 %为标准 ,两组间无显著差异 (P >0 .0 5)。曲唑酮主要副作用是头晕和嗜睡 ,氟西汀是引起焦虑和睡眠障碍。Objective To evaluate the efficacy and side effects of Fluoxetine and Trazodone in the treatment of depressive episodes.Methods 60 patients with depressive episodes were randomly assigned into Fluoxetine group(30 cases, 50～150mg/d)for 4 weeks. Efficacy were determinated with the Hamilton rating scale for depression(HAMD) and side effects(SERS).Results Both Fluoxetine and Trazodone could alleviate the depression symptoms with similar efficacy. The total score of HAMD was significantly decreased after treatment with Fluxetine and trazodone (P≤0.001).But no significant differences were found between two groups. The side effects of Fluoxetine was anxiety and Trazodone was dizzy giddy and faligue. Conclusion Trazodone was effective and safe drug, especially could improve sleep for treating the depressive episodes.

关 键 词：曲唑酮 氟西汀 抑郁症 治疗 副作用 疗效 

分 类 号：R-5[医药卫生]