氟西汀联合利培酮治疗抑郁症的对照研究  

A comparative study of the efficacy between fluoxetine combined with risperidone and fluoxetine alone in the treatment depression

作　　者：路英智[1] 任清涛[1] 田明萍[1] 

机构地区：[1]山东省淄博市精神病医院,山东淄博255100

出　　处：《中国行为医学科学》2003年第1期47-48,共2页Chinese Journal of Behavioral Medical Science

摘　　要：目的　观察氟西汀联合利培酮治疗抑郁症的疗效和副作用。方法　将 96例抑郁症患者随机分成两组 ,分别给予氟西汀与氟西汀联合利培酮治疗 6周 ,用汉密尔顿抑郁量表 (HAMD)和汉密尔顿焦虑量表 (HAMA)评定疗效 ,用副反应量表 (TESS)观察副作用。结果　两组间HAMD和HAMA减分率于第 1、2、6周末比较均有显著性差异 (P <0 .0 5～ 0 .0 1 )。而TESS各周无明显差异。结论　氟西汀联合利培酮治疗抑郁症的疗效优于单用氟西汀 。Objective To observe the efficacy and side effects of fluoxetine combined with risperidone in the treatment of depression. Methods 96 patients with depression were randomly assigned into two groups treated respectively,such as fluoxetine combined with risperidone and fluoxetine alone for 6 weeks in order to evaluate efficacy and side effects with HAMD,HAMA and TESS after 1,2,6 week . Results There were differences of decreased scores of HAMD,HAMA between the two groups patients after 1,2,6 week respectively(P<0.05～0.01).There were no differences of scores of TESS between the two groups patients after 1,2,6 week respectively (P>0.05). Conclusions Fluoxetine Combined with risperidone was much better than fluoxetine alone , and the side effects were not increased.

关 键 词：氟西汀 利培酮 抑郁症 疗效 副作用 

分 类 号：R749.4[医药卫生—神经病学与精神病学]