急性应激大鼠脑组织NO、SOD含量变化及意义  

Changes and significance of nitric oxide and superoxide dismutase in limbic system of the rats under acute stress

作　　者：胡淑芳[1] 刘光雄[1] 王惠利[1] 邓自和[1] 何江萍[1] 马文涛[1] 

机构地区：[1]解放军第三医院精神科,陕西宝鸡721004

出　　处：《西北国防医学杂志》2003年第2期127-128,共2页Medical Journal of National Defending Forces in Northwest China

基　　金：兰州军区医药卫生基金资助项目 (LXH0 2 - 0 3)

摘　　要：目的 :观察急性应激大鼠脑组织一氧化氮 (NO)含量和超氧化物歧化酶 (SOD)活力变化 ,探讨其在急性应激障碍发病中的作用。方法 :通过建立急性应激模型 ,分别取脑边缘系统大脑额叶、海马、下丘脑及中脑 ,制成脑组织匀浆测定NO的含量和SOD的活力。结果 :急性应激组大鼠大脑额叶、海马、下丘脑及中脑组织SOD活力明显高于对照组 (P <0 .0 5) ,NO含量在海马、下丘脑升高明显 (P <0 .0 5)。结论 :结果提示 ,在应激反应过程中自由基对脑有损害作用 ,可能参与应激障碍的发病。Objective:To observe the changes of nitric oxide (NO) and superoxide dismutase(SOD) in the rats under acute stress,and study the effects of NO and SOD on stress disorder.Methods:Acute stress model was established by forced swimming, the level of NO and the activity of SOD were measured in hippocampus,prefrontal,hypothalamus and midbrain.Results:The level of NO in hippocampus and hypothalamus in stress group was significantly higher than that of control group ( P <0.05),SOD activity in hippocampus,prefrontal,hypothalamus and midbrain in stress group was significantly higher than that of control group( P <0.05).Conclusion:NO and SOD may have effect on stress disorder.

关 键 词：脑损伤 应激 边缘系统 一氧化氮 超氧化物歧化酶 急性应激 大鼠 

分 类 号：R363[医药卫生—病理学]