喉癌患者无癌侵及的喉内肌与正常喉内肌的组织学差异  

Histological Difl'crences of Intrinsic Laryngeal Muscle Between Patients With Laryngeal Carcinoma and Healthy Adult

作　　者：李君[1] 魏宏权[2] 聂士清[1] 杨式麟[1] 

机构地区：[1]中国医科大学附属第二医院耳鼻咽喉科,辽宁沈阳110004 [2]中国医科大学附属第一医院耳鼻咽喉科

出　　处：《中国医科大学学报》2003年第2期128-130,共3页Journal of China Medical University

摘　　要：目的:通过对喉癌患者未被癌组织侵及的喉内肌及正常人的喉内肌肌纤维形态、结构的比较分析,从组织学角度揭示二者之间的差异。方法:将5例喉癌患者未被癌组织侵及的肌纤维和1例健康成人的甲杓肌、环杓侧肌及环杓后肌经HE染色,于镜下观察肌纤维的形态,并采用显微图像分析仪测量肌纤维的横截面积和最大宽度。结果:喉癌患者与健康成人相比,各喉内肌肌纤维形态差异较大;肌纤维横截面积、最大宽度有显著增加(P<0.01),增加的幅度均为环杓后肌>环杓侧肌>甲杓肌。结论:喉癌患者未被癌组织侵及的肌纤维不仅在形态上有很大的不同,而且肌纤维横截面积及最大宽度明显增大,可能是癌变增加了呼吸道的阻力,各喉内肌代偿性活动的结果。Objective: A histological study on intrinsic laryngeal muscle was performed in healthy adult and laryn-geal carcinoma patients to investigate the morphologic changes. Methods: The intrinsic laryngeal muscles were taken from total laryngeetomy specimens with carcinoma (5cases) and 1 healthy adult. With HE staining and photo micrograph, morphologic characteristics of muscle fiber were studied, such as fiber shape,cross-sectional fiber area, and maximum width. Results: Compared with the normal specimen, a marked difference in intrinsic laryngeal muscle of laryngeal carcinoma patients was found. The cross sectional fiber area and the maximum width increased significantly in patients ( P < 0. 01 ). Conclusion: The hislologic differences may be due to compensatory contraction of intrinsic laryngeal muscle in patients.

关 键 词：喉癌 喉内肌 肌纤维 HE染色 甲杓肌 环杓侧肌 

分 类 号：R739.65[医药卫生—肿瘤]