HLA-A,B,C抗原在原发肺癌及其淋巴结转移灶中的表达  

Expression of Human Leucocyte Antigen-A, B, C in Primary Lung Carcinomas and Metastatic Lymph Nodes

作　　者：王威[1] 李军[2] 李玉[1] 

机构地区：[1]中国医科大学附属第一医院胸外科 [2]铁岭市中心医院外科

出　　处：《中国医科大学学报》2003年第2期151-153,共3页Journal of China Medical University

摘　　要：目的:研究肺癌及其淋巴结转移灶中人类白细胞抗原(HLA-A,B,C)的表达情况,并探讨其临床意义。方法:用抗HLA-A,B,C单克隆抗体W6/32,以免疫组化S-P法检测67例肺癌和23例肺癌淋巴结转移灶中HLA-A,B,C抗原的表达。结果:6例小细胞肺癌,27例鳞癌和34例腺癌中HLA-A,B,C抗原表达下降率分别为100％,66.6％和38.2％,后两者相比差异有统计学意义(P<0.05);非小细胞肺癌中随着肿瘤分化程度下降,HLA-A,B,C抗原缺失率将增加(P<0.05),而与病人的TN分期无关;转移灶中HLA-A,B,C抗原的表达与其原发灶中相比普遍减低(P<0.05)。结论:HLA-A,B,C抗原在肺癌中的表达明显低于正常肺组织;且与肺癌的组织类型和分化程度相关。Objective: Our aims were to study the expressions of human leucocyte antigen (HLA-A,B,C) in primary lung carcinomas and the metastatic focus and to discuss their clinical significance. Methods: Using the monoclonal antibody against HLA-A,B,C antigens ( w6/32) , we detected the expression of human leucocyte antigen in 67 primary lung tumors and 23 metastatic focus through the immunohistochemical S-P method. Results: The declension rate of the expression of HLA-A,B,C in small cell carcinoma was 100% , in squamous cell carcinoma 66.6% , and in adenocarcinoma 38. 2%. The discrepancy between these results was of statistical importance (P < 0. 05). The declension rate of HLA-A, B, C antigens increased with the decreasing of tumor's differentiation in NSCLC ( P < 0. 05 ) , but there was no significant relation between the rate and TN stage of the patients. The expression of HLA-A, B, C antigen in metastatic focus were more deficient than those in the primary tumors (P < 0. 05). Conclusion: The expression of HLA-A,B,C antigen is obviously lower in lung cancer than that in normal lung, and is correlated with tumors tissue type and differentiation degree.

关 键 词：主要组织相容性复合物 HLA-I类抗原 肺癌 淋巴结转移 

分 类 号：R734.2[医药卫生—肿瘤]