多层螺旋CT灌注成像在全身肿瘤性病变中的初步应用  

Preliminary application of perfusion imaging in neoplasms in the brain and body with multislice helical CT

作　　者：李智勇[1] 伍建林[1] 宁殿秀[1] 王克礼[1] 韩睿[1] 刘晓风[1] 郎志谨[1] 

机构地区：[1]大连医科大学附属第一医院放射科,辽宁116011

出　　处：《放射学实践》2003年第4期297-300,共4页Radiologic Practice

摘　　要：目的 :初步评价多层螺旋CT(MSCT)肿瘤灌注成像方法及其临床应用价值。方法 :对 1 0例肿瘤患者行MSCT灌注成像 ,先用常规CT平扫确定肿瘤中心部位 ,然后进行肿瘤灌注扫描 ,采用电影扫描技术 (1r/s) ,层厚 1 0mm/2i;注药流率 3 .5～ 4 .0ml/s,剂量 45～ 50ml,延迟时间 5s,扫描总时间 45s。扫描图像经ADW 3 .1工作站处理 ,计算并分析灌注图像和灌注参数 ,包括血流量 (BF)、血容量 (BV)、平均通过时间 (MTT)和表面通透性 (PS)。结果 :所有肿瘤的灌注图像均可以清晰直观的显示出肿瘤大小和轮廓 ,并可定量检测肿瘤内部的组织灌注状态 ,在脑肿瘤中清晰区分肿瘤区与水肿区。所有肿瘤灌注参数均明显增高。体部肿瘤灌注成像受呼吸运动影响较大。结论Objective:To evaluate methods of perfusion imaging in neoplasms with multi slice helical CT and its clinical application value.Methods:Ten patients with newly diagnosed neoplasms underwent perfusion imaging with mutislice helical CT (MSCT).At first plain CT scan was performed to localize central slices of tumor,then perfusion imaging of neoplasms was undergone using cine scan (1 rotate/s),slice thick 10mm/2i,injecting dosage 45～50ml,injecting rate 3.5～ 4.0ml/s, scanning delay time 5s,scanning total time 45s.Scanning images were transferred into ADW3.1 work station to create and analyze perfusion images and parameters,including blood flow(BF)?blood volume(BV)?mean transit time(MTT) and permeability surface (PS).Results:Perfusion images of all neoplasms can clearly and directly display tumor diameter and outlines and quantitatively monitor blood perfusion status of tumor inner structures,clearly differentiate edema and tumor in cerebral neoplasms.Perfusion parameters of all neoplasms showed remarkable increase.Body tumors were liable to be interfered by breath movement.Conclusion:MSCT perfusion imaging provides a precise and relative simple method to quantitatively estimate blood perfusion status in tumor of the body.The technique can be easily implemented and it opens up broad prospects for clinical application.

关 键 词：肿瘤 诊断 多层螺旋CT灌注成像 临床应用 

分 类 号：R730.4[医药卫生—肿瘤]