不同输血方式对肺鳞癌患者围术期TNF-α和IL1-0的影响  

Effects of Different Methods of Blood Transfusion on the Serum Levels of TNF-α and IL-10 in Patients with Pulmonary Squamocellular Cancer During Perioperative Period

作　　者：盛斌[1] 龙建平[1] 付金海[1] 熊卫民[1] 汪更胜[1] 黄标通[1] 

机构地区：[1]中国人民解放军第一六三中心医院,湖南长沙410003

出　　处：《医学临床研究》2003年第4期266-268,共3页Journal of Clinical Research

摘　　要：目的探讨同种输血和自体输血对肺鳞癌患者围术期肿瘤坏死因子 α(TNF α)和白细胞介素 10(IL 10 )的影响和相互关系。方法2 0 0 1年 1月至 2 0 0 3年 1月对 31例肺鳞癌患者行肺癌根治术 ,将其分为两组 ,同种输血组 (A组 ) 17例 ,自体输血组 14例 (B组 )。测定两组围术期血清中TNF α和IL 10的浓度。结果A组输血后d1与输血前相比血清中TNF α、IL 10浓度增高 ,以IL 10变化尤为明显 ,输血后d5TNF α降低并接近输血前的水平 ,明显低于B组 ,IL 10仍明显高于输血前的水平。B组中不同时间IL 10无显著变化 ,TNF α于d5明显高于输血前。结论肺鳞癌患者围术期同种输血后血清中TNF α降低与IL 10升高有关 ,IL 10升高可能是同种输血后免疫抑制的重要原因。ObjectivesTo study effects of allogenic and autologous blood transfusions on the serum levels of tumor necrosis factor α(TNF α) and interleukin 10 (IL 10) in patients with pulmonary squamocellular cancer (PSC) during perioperative period.MethodsTransthoracic eradicative operations of lung cancers were performed in thirty one PSC patients from Jan.,2001 to Jan., 2003. They were divided into two groups:①Group A—allogenic blood transfusion in 17 patients and ②Group B—autologous blood transfusion in 14 patients. Serum levels of TNF α and IL 10 were estimated and the related data were compared between both groups.ResultsIn Group A, the serum levels of TNF α and IL 10 increased on the first day after transfusion, showing significant elevation of IL 10 (P<0.01). On the 5th day, the serum levels of TNF α declined and nearly returned to pretransfusion figures, which were obviously lower than those in Group B(P<0.01); while the serum levels of IL 10 remained higher than pretransfusion results. As for Group B, the serum levels of IL 10 displayed no distinct change at different duration, but those of TNF α were higher than their levels before transfusion (P<0.01).ConclusionA decrease of serum TNFα levels in PSC patients subjected to allogenic blood transfusion is probably related to the elevation of IL 10 during perioperative period. IL 10 elevation may be one of important causes of immunosuppression following allogenic blood transfusion. This kind of immunosuppression can be alleviated by autologous blood transfusion. [

关 键 词：输血方式 肺鳞癌 患者 围术期 TNF-Α 肿瘤坏死因子-α 白细胞介素10 

分 类 号：R734.2[医药卫生—肿瘤]