孔石莼多糖降血脂活性的初步研究  

A preliminary study on antilipemic activity of polysaccharides from Ulva pertusa in mice

作　　者：王艳梅[1] 李智恩[1] 牛锡珍[1] 张虹[1] 张全斌[1] 

机构地区：[1]中国科学院海洋研究所,山东青岛266071

出　　处：《中国海洋药物》2003年第2期33-35,共3页Chinese Journal of Marine Drugs

基　　金：九五国家重点科技攻关项目"海洋生物多糖新药"专题(项目编号:96-C02-04-04)

摘　　要：为开发我国的孔石莼资源,在研究了其多糖化学组成的基础上,进行了孔石莼多糖对高脂血症的活性研究。结果表明:3个剂量的多糖样品组均有显著的降甘油三酯作用;中、高剂量组可显著降低血清中总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C),升高高密度脂蛋白胆固醇(HLD-C)从而增加HDL-C/TC的比值;高剂量组的降脂活性与阳性对照药烟酸肌醇酯相近;血清中脂蛋白胆固醇的改善状况有明显的剂量依赖性。并对孔石莼多糖降血脂活性的机理进行了讨论。The antilipemic activity of ulvan in mice was studied based on the study of the physico-chemical properties of ulvan (polysaccharides from Ulva pertusa). The result revealed that three ulvan dose groups had significant activity to lower the levels of TG; Both middle and high dose groups can lower the levels of TC,TG,LDL-C and increase HDL-C/TC in the serum. High dose group also can enhance HDL-C content significantly. Effects of ulvan on LDL-C,HDL-C,. HDL-C/TC were dose-dependent. The activity of high dose ulvan group was very similar to the positive control group in the same dose.

关 键 词：孔石莼多糖 降血脂活性 研究 高脂血症 生物活性 

分 类 号：R589.2[医药卫生—内分泌] R972.6[医药卫生—内科学]