L-羟基脯氨酸键合手性配体交换色谱固定相的制备及手性拆分  

Preparation of L-Hydroxyproline Chiral Stationary Phase for Ligand Exchange Chromatography and Their Applications

作　　者：祝馨怡[1] 张玉华[1] 孙伟[1] 刘霞[1] 李永民[1] 陈立仁[1] 

机构地区：[1]中国科学院兰州化学物理研究所,兰州730000

出　　处：《分析科学学报》2003年第2期124-126,共3页Journal of Analytical Science

基　　金：中国科学院重点基金 ( No.KY95 -S1 -2 0 5 )

摘　　要：合成出了 L -羟基脯氨酸键合手性配体交换固定相 ,用元素分析和红外光谱对固定相进行了表征。该固定相在反相条件下 ,以水作流动相 ,对 DLL Hydroxyproline chiral stationary phase for ligand exchange chromatography was prepared by treating silica gel with 3 glycidoxypropyltrimethoxysilane and bonding L hydroxyproline. Some DL amino acids were separated by ligand exchange chromatography with this chiral stationary phase.

关 键 词：固定相 手性拆分 L-羟基脯氨酸 手性配体 异构体 分离 DL-氨基酸 交换色谱 

分 类 号：Q517[生物学—生物化学] O629.711[理学—有机化学]