肝癌三维彩色血管能量成像与病理微血管密度研究  

Study on primary hepat ocarcinomas with three-dimensional color power angiography and microvessel density of tumor immunohistochemistry

作　　者：曾燕荣[1] 赵玉珍[2] 王顺祥[2] 翟栋材[2] 房勤茂[2] 杨漪[2] 孙心平[2] 薛逊[2] 李景胜[2] 

机构地区：[1]北京市通州潞河医院超声科,北京101149 [2]河北医科大学四院,河北石家庄050011

出　　处：《中国临床医学影像杂志》2003年第2期105-107,共3页Journal of China Clinic Medical Imaging

基　　金：河北省科委重点研究项目[962161124D]

摘　　要：目的:探讨三维彩色血管能量成像(three-dimensionalcolorpowerangiography,3D-CPA)检测肝癌血管的临床价值。方法:应用3D-CPA检测37例原发性肝癌(PrimaryHepatocarcinomas,HCC)肿瘤血供及血管分布情况,计测肿瘤血管指数(VascularityIndex,VI),术后肿瘤组织切片行CD34单克隆抗体免疫组化染色,计数肿瘤微血管密度(MicrovesselDensity,MVD),对上述结果进行分析。结果:37个肝癌病灶VI为0.2647±0.1249条?cm3,免疫组化计测MVD为(63.31±29.93)?400倍视野,两者比较呈高度线性正相关(r=0.874,P<0.001)。结论:3D-CPA能客观评价肝癌血供,较准确地定量其血管,为临床定性诊断、估测预后及疗效判定提供依据。Objective:To evaluate the clinical value of three-dimensional color power angiography (3D-CPA)in detecting vessels of primary hepatocarcinomas (HCC).Methods:Vessels of 37HCCs were performed with3D-CPA preoperatively.The vascular patterns were assessed and vascularity index (VI)were calculated for every tumor.After operation,immunohistochem-istry was performed using CD 34 monoclonal antibody and microvessel density(MVD)was calculated by staining blood vessels per high-power field.The results were analyzed respectively.Results:The VI of 37HCCs was(0.2647±0.1249)*/cm 3 ,and the MVD of them was(63.31±29.93)*/400×.They showed a significant positive linear correlation(r=0.874,P<0.001).Con clu-sions:3D-CPA can evaluate blood supply of HCC objectively and quantitate the vessels more accurately.It can play an im-portant role in clinical diagnosis,prognosis and assessment of the treatment effect.

关 键 词：肝肿瘤 超声检查 多普勒 彩色 

分 类 号：R735.7[医药卫生—肿瘤] R445.1[医药卫生—临床医学]