E-钙黏附素和基质金属蛋白酶-2的表达变化及与胃癌侵袭和转移的关系  

Differential Expression of E-cadherin and Martrix Metalloproteinase-2 Genes Associated with the Invasion and Metastasis of Tumor Cell in Human Gastric Cancer

作　　者：汪泳[1] 刘昕[1] 朱任之[1] 杨树琛 张建刚[1] 钱震[3] 

机构地区：[1]兰州医学院病理生理学教研室,甘肃兰州730000 [2]定西地区医院,甘肃定西743000 [3]兰州军区总医院,甘肃兰州730000

出　　处：《肿瘤防治杂志》2003年第3期280-282,共3页China Journal of Cancer Prevention and Treatment

摘　　要：目的 :探讨E cadherin和MMP 2在胃癌组织中的表达与胃癌浸润转移的相关性。方法 :采用S P免疫组化染色 ,检测 83例胃癌组织的E cadherin和MMP 2的表达情况 ,2 0例胃良性病变手术病例作对照。结果 :正常胃黏膜E cadherin呈强阳性表达 ,胃癌组织中E cadherin表达率明显减低 ,阳性表达率为 16 9% (14 83) ;E cadherin表达减低与胃癌细胞分化程度、浸润深度、浸润型生长、淋巴结转移密切相关 (P <0 0 5 ) ,而与TNM分期及肿瘤大小无关。MMP 2在正常胃黏膜中呈阴性表达 ,在胃癌组织中表达呈阳性 ,阳性率为 78 3% (6 5 83) ;MMP 2表达强度与胃癌分化程度、淋巴结转移、浸润深度、浸润型生长、TNM分期显著相关 (P <0 0 5 ) ,而与肿瘤大小无关。E cadherin与MMP 2的表达调控呈负相关 ,两者的表达水平呈负相关性。结论 :E cadherin的表达下调和MMP 2表达上调与胃癌浸润和转移密切相关 。Objective To investigate the expression of E cadherin and Martrix metalloproteinase 2(MMP 2) in human gastric cancer and their relationship with tumor cell invasion and metastasis.Methods The expressions of E cadherin and Matrix metalloproteinase 2 in gastric mucosa were detected in 20 cases of healthy control group,83 cases of gastric cancer by using streptavidin peroxidase immunohistochemistry.Results All of normal gastric mucosa abundantly expressed E cadherin,but did not express MMP 2.The incidences of E cadherin and MMP 2 expressed were 16 9% and 78 3% respectively in the gastric cancer group.The related factors with E cadherin expression reduced were lower differentiation,deep invaded,invaded growth and lymphaden metastasis of gastric cancer cell.The related factors with MMP 2 expression were the differentiation degree,lymphaden metastasis,deep invaded,invaded growth and TNM stage of gastric cancer.The non related factors with E cadherin expression reduced were the TNM stage and the size of gastric cancer.The non related factor with MMP 2 expression was the size of gastric cancer.Conclusions The expressions of E cadherin and MMP 2 are significantly related with the invading and transferring of gastric cancer.The changes of the two factors expressing can help the judgment of the prognosis of gastric cancer. China J Cancer Prev Treat,2003,10(3):280-282 Key words:E cadherin;MMP 2;stomach neoplasms/pathology;immunohistochemistry

关 键 词：E-钙黏附素 基质金属蛋白酶-2 胃肿瘤/病理学 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]