血清CⅣ、尿THP、Alb预测糖尿病视网膜病变  

Combined Determination of Serum Type Ⅳ Collagen with Urine Tamm-HorsfallProtein and Albumin for Early Diagnosis in Diabetic Retinopathy

作　　者：王虹[1] 张爱华[1] 任玉国[1] 

机构地区：[1]山东省莱芜市人民医院核医学科,271100

出　　处：《放射免疫学杂志》2003年第2期76-78,共3页Journal of Radioimmanology

摘　　要：目的 :探讨 2型糖尿病 (DM)患者血清Ⅳ型胶原 (CⅣ )、尿Tamm -Horsfall蛋白 (THP)、白蛋白(Alb)的变化与糖尿病视网膜病变 (DR)的关系。方法 :采用酶联免疫法及放射免疫分析 ,分别对 76例 2型DM患者及 3 0例正常人的血清CⅣ、尿THP、Alb进行检测。结果 :三种方法检测在非增殖型视网膜病变组 (BDR)、增殖型视网膜病变组 (PDR)与无视网膜病变组 (NDR)各组间相比存在显著差异 (p分别为 <0 0 1;<0 0 1;<0 0 0 1)。结论 :血清CⅣ、尿THP、Alb检测可作为预测 2型DM患者DR的敏感指标。Objective To study the relationship between changes of serum type Ⅳ collagen, urine Tamm-horsfall protein, albumin and development of diabetic retinopatthy (DR) in patients with type 2 diabetes mellitus. Methods Serum CⅣ, urine THP were determined with ELISA and RIA respectively. Alb in 76 patients with type 2 diabetes mellitus (NDR26, BDR26, PDR24) and 30 controls. Results Values of the three markers were significantly different among the three groups of patients ( p <0 01; p <0 01; p <0 001 respectively). Conclusion Serum type Ⅳ collagens, urine Tamm-Horsfall protein and ablumin were sensitive indicators in predicting diabetic retinopathy.

关 键 词：血清 CⅣ 尿 THP ALB 预测 糖尿病视网膜病变 TAMM-HORSFALL蛋白 白蛋白 微血管病变 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]