恒磁场对大鼠血液流变学及一氧化氮含量的影响  

Effect of constant magnetic field on rats during the blood reperfusion after cerebral ischemia

作　　者：关微华[1] 马波[1] 朱翔[1] 陈丽娜[1] 许艳[1] 高佩琦[1] 

机构地区：[1]哈尔滨医科大学生物物理教研室,黑龙江哈尔滨150086

出　　处：《中国医学物理学杂志》2003年第2期122-123,126,共3页Chinese Journal of Medical Physics

基　　金：黑龙江省自然科学基金资助项目D9901

摘　　要：本研究通过建立大鼠前脑缺血再灌注损伤模型,然后应用恒磁场进行照射,10天后眼球取血,断头取脑观察其血液流变学指标,NO(一氧化氮)、NOS(一氧化氮合成酶)、GSH-PX(谷胱甘肽过氧化物酶)含量影响。实验结果表明,恒定磁场通过降低血液粘度,改善血液循环状态;降低NO对神经细胞的毒性作用;升高GSH-PX的活力,维持一定量的GSH对血脑屏障的保护作用,减轻缺血后脑水肿,对脑缺血再灌注损伤起到一定的保护作用。In order to study the effect of constant magnetic field on rats during the blood reperfusion after cerebral ischemia. we formed the cerebral ischemia model according to smith's method, then treated them by 40 mT constant magnetic field. Ten days later, the hemorrheology, NO, NOS and GSH-PX were observed. The results show that constant magnetic field can improved GSH-PX activity and hemorrheology, reduce No and NOS level. It has treatment effect for the reperfusion damage after ischemia.

关 键 词：恒磁场 血液流变学 一氧化氮 脑缺血 再灌注损伤 

分 类 号：R743.31[医药卫生—神经病学与精神病学] R331.1[医药卫生—临床医学]