ACE-1基因多态性与缺血性脑卒中的遗传易感性研究  

Polymorphisms of ACE-l gene and genetic susceptibility of ischemic stroke

作　　者：李才明[1] 张成[1] 邱淑莲[2] 卢锡林[1] 曾缨[1] 吴海新[3] 陈伟奇[2] 罗伟良[2] 刘集鸿[4] 

机构地区：[1]中山大学第一附属医院神经科,广东广州510080 [2]广东省惠州市中心人民医院神经科,广东惠州516001 [3]广东省惠州市中心人民医院药检室,广东惠州516001 [4]广东省惠州市中心人民医院消化实验室,广东惠州516001

出　　处：《中风与神经疾病杂志》2003年第2期137-139,共3页Journal of Apoplexy and Nervous Diseases

基　　金：国家自然科学基金 ( 30 170 337);广东省自然科学基金( 970 0 6 1);卫生部临床重点项目基金 ( 2 0 0 132 1);CMB基金 ( 6 6 7);教育部骨干教师基金 ( 0 82 0 0 4 )

摘　　要：目的　研究血管紧张素 - 1转换酶 ( ACE- 1)基因多态性与缺血性脑卒中 ( IS)的关系。方法　运用多聚酶链反应 ( PCR)技术检测 143例 IS及 15 4例对照组患者 ACE- 1基因多态性。结果　 IS组 ACE- 1基因 DD基因型和 D等位基因与对照组比较差异无统计学意义 ;重型组 ID基因型与对照组相比有统计学意义 ,D等位基因与临床IS相关。结论　 ACE- 1基因 ID基因型可能是 IS危险因子 ,ID基因型与重型 IS有关。Objective To study the relationship between polymorphisms of ACE-1 gene and ischemic stroke (IS).Methods 143 IS patients and 154 controls were recruited in the study,their polymorphisms of ACE-1 gene were analyzed by polymerase chain reaction (PCR).Results There were no significant difference between the frequencies of DD genotype and D allele of ACE-1 gene in IS patients and those in controls,but there were association between ID genotype and serious IS and between D allele and clinical IS.Conclusion ID genotype of ACE-1 gene may be the risk factor of IS.ID genotype is associated with serious IS.

关 键 词：ACE-l基因多态性 缺血性 脑卒中 遗传易感性 研究 

分 类 号：R743.3[医药卫生—神经病学与精神病学]