射频热凝治疗对肝癌血浆肿瘤坏死因子及可溶性受体Ⅰ的影响  

Effects of Radiofrequency Ablation on Plasma TNF αand sTNFR-Ⅰ in Patients with Primary Hepatic Carcinoma

作　　者：刘超[1] 庞志刚[1] 王广田[1] 

机构地区：[1]河南郑州大学第二附属医院普外科,450003

出　　处：《中国误诊学杂志》2003年第4期499-500,共2页Chinese Journal of Misdiagnostics

摘　　要：目的　探讨射频热凝治疗对肝癌患者血浆肿瘤坏死因子及可溶性受体 的影响。方法　分别用放射免疫法和 EL ISA法检测 18例健康人和 32例肝癌 PRFA前后 TNFα及 s TNFR 水平。结果　肝癌组血浆 TNFα(1.71ng/ml± 0 .2 5 ng/ml)及 s TNFR- (30 72 .4 pg/ml± 6 5 0 .7pg/ml)均明显高于健康对照组 (1.2 1ng/m l± 0 .19ng/ml,P<0 .0 0 1;15 38.6 pg/m l± 4 78.3pg/ml,P <0 .0 0 1) ;PRFA后 s TNFR- 显著下降 (2 392 .5 pg/ml± 5 4 8.8pg/ml,P <0 .0 0 1) ,但 TNFα无明显变化 (1.73ng/ml± 0 .2 7ng/ml,P>0 .0 5 )。结论　PRFA可通过降低 s TNFR- 改善肝癌患者免疫状态。Objective To investigate the effect of percutaneous radiofrequency ablation(PRFA) on tumor necrosis factor α(TNFα) and soluble TNFα receptor Ⅰ(sTNFR Ⅰ) in plasma in patients with primary hepatic carcinoma (PHC).Methods TNFα and sTNFR Ⅰlevels in 32 PHC patients and 18 healthy subjects were determined by radioimmunoassay and ELISA respectively.Results Both TNFα and sTNFR Ⅰ levels in patients were significantly higher than those in healthy subjects; PRFA could significantly reduce sTNFR Ⅰ,and had no effects on TNFα.Conclusions PRFA could improve the immunologic status of patients with PHC by decreasing sTNFR Ⅰ.

关 键 词：射频热凝治疗 肝癌 血浆肿瘤坏死因子 可溶性受体I 影响 

分 类 号：R735.705[医药卫生—肿瘤]