原发性十二指肠恶性肿瘤的诊断与治疗  

Diagnosis and treatment of primary duodenal malignant tumors

作　　者：刘全达[1] 蔡志民[2] 何振平[1] 姜军[2] 吴国庆[2] 董家鸿[1] 

机构地区：[1]第三军医大学全军肝胆外科研究所,西南肝胆外科医院重庆400038 [2]第三军医大学西南医院普外科,重庆400038

出　　处：《中国普通外科杂志》2003年第4期258-261,共4页China Journal of General Surgery

摘　　要：目的　探讨原发性十二指肠恶性肿瘤的临床病理特征及其诊断和治疗。方法　回顾分析经病理证实的 47例原发性十二指肠恶性肿瘤的临床表现、病理类型、诊断和治疗手段。结果　病理类型为腺癌 42例、平滑肌肉瘤 4例、类癌 1例 ;好发部位为降段 (35例 ) ,尤其是乳头区 (2 8例 )。常见临床表现依次为上腹疼痛、黄疸、消化道出血、肠梗阻、体重减轻。诊断手段为纤维胃十二指肠内镜、胃肠钡餐、逆行性胆胰管造影 (ERCP )、B超及CT检查。本组行胰十二指肠切除术 2 5例和姑息性手术 2 0例。手术死亡率 2 .2 % (1/45 ) ,术后并发症 2 0 .0 % (9/45 )。胰十二指肠切除术对Ⅰ～Ⅲ期腺癌治疗效果好 ,3,5年生存率分别达 5 0 .0 %和 31.8% ,姑息性手术无获得长期生存者。结论　原发性十二指肠恶性肿瘤以腺癌为主 ,早期临床表现无特异性 ,主要依据B超、CT和ERCP诊断 ,对无远处转移的肿瘤应积极争取根治性胰十二指肠切除。Objective To investigate the clinicopathological characteristics, diagnosis and treatment of primary duodenal malignant tumors (PDMTs). Methods The clinical data of 47 PDMTs confirmed by pathology were retrospectively analyzed. Results Pathological types were adenocarcinoma in 42 cases, leiomyosarcoma in 4, and carcinoid in 1.The most common location of the tumor was the descending portion (35), especially the peri-papillary region (28) of the duodenum. The most common symptoms and signs were abdominal pain, jaundice, upper gastrointestinal hemorrhage, obstruction ,and weight loss. The main diagnostic modalities were gastroduodenoscopy, GI barium meal, ERCP, ultrasound (US) and CT. US together with ERCP was the most useful in improving the diagnosis of peripapilla tumors in the duodenum. Panceraticoduodenectomy and some palliative procedures were performed for 25 and 20 cases, respectively.Surgical mortality and postoperative morbidity were 2.2% (1/45) and 20% (9/45),retrospectively. The 3-year and 5-year survival for those adenocarcinoma without distant metastasis undergoing pancreaticoduodenectomy were 50% and 32%. No long survival was found after the palliative operation. Conclusions Adenocarcinoma is the most common pathological type of PDMTs.No specific symptoms were shown in the early stage of PDMTs, US, CT and ERCP are the main diagnostic procedures. Radical pancraticoduodenectomy can prolong survival time and should be attempted for those without systemic dissemination.Palliative operations should be considered for tumors in advanced stage.

关 键 词：十二指肠肿瘤/诊断 十二指肠肿瘤/外科学 腺癌/诊断 腺癌/外科学 

分 类 号：R735.1[医药卫生—肿瘤] R730.261[医药卫生—临床医学]