文拉法辛缓释胶囊与丁螺环酮治疗广泛性焦虑症的临床比较研究  

A clinical comparison study of venlafaxine sustained release capsules vs buspirone in treatment of general anxiety disorder

作　　者：林建荣[1] 黄煜坤[1] 张春萍[1] 陆泳[1] 邹志方[2] 谭静卿[1] 

机构地区：[1]广州市精神病医院,广东广州510370 [2]广东药学院,广东广州510224

出　　处：《中国新药与临床杂志》2003年第5期269-272,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :比较文拉法辛缓释胶囊 (简称文拉法辛 )和丁螺环酮治疗广泛性焦虑症的疗效和安全性。方法 :广泛性焦虑症病人 5 3例 [男性 1 9例 ,女性 3 4例 ,年龄 (2 8±s 5 )a,病程 (1 4± 3 )mo]采用文拉法辛 (97± 8)mg,75～ 2 2 5mg·d-1,po,qd,疗程为 8wk。另用丁螺环酮治疗同类病员 5 4例 [男性 2 1例 ,女性 3 3例 ,年龄 (2 7± 6)a,病程 (1 6± 4)mo],用量(3 1± 4)mg ,1 5～ 45mg·d-1,po,qd,疗程为 8wk。在治疗前及治疗后 1 ,2 ,4,8wk末予HAMA ,CGI,TESS量表评定临床疗效和不良反应。结果 :文拉法辛组显效率 79% ,丁螺环酮组显效率 74% ,2组疗效差异无显著意义 (P >0 .0 5 ) ,文拉法辛组不良反应较丁螺环酮组少。结论 :文拉法辛与丁螺环酮治疗焦虑症疗效相当 ,前者较后者起效快 。AIM: To compare the efficacy and safety of venlafaxine sustained release capsules (venlafaxine) and buspirone in treating general anxiety disorder. METHODS: Fifty three patients with general anxiety disorder in venlafaxine group [M 19,F 34; age (28± s 5)a, course (14±3) mo] were treated with venlafaxine (97±8)mg, 75-225 mg·d -1 , po , qd, for 8 wk. Other fifty four patients of the buspirone group (M 21, F 33; age (27±6)a, course (16±4) mo were treated with buspirone (31±4)mg, 15-45 mg·d -1 , po , qd, for 8 wk. HAMA, CGI, and TESS were assessed before and after 1,2,4,8 wk of treatment. RESULTS: The obvious effective rate in venlafaxine group was 79% while 74% in buspirone group. No statistically significant difference was noted between the two groups ( P > 0.05 ). But the adverse reactions in venlafaxine group were less than that in buspirone group. CONCLUSION: The effect of venlafaxine is similar to buspirone in the treatment of general anxiety disorder. The onset of action of the former is quicker than that of the latter. The adverse reactions of venlafaxine are less than that of buspirone.

关 键 词：焦虑症 文拉法辛缓释胶囊 丁螺环酮 临床疗效 比较 

分 类 号：R749.72[医药卫生—神经病学与精神病学] R971.43[医药卫生—临床医学]