干酪菌发酵产物对小鼠小肠推进功能的影响  

The experimental studies of ZPL on the intestinal propulsive movement in mice

作　　者：王君[1] 邹原[1] 宫德正[2] 陆海峰[1] 杜昱光[1] 

机构地区：[1]中国科学院大连化学物理研究所 [2]大连医科大学,辽宁大连116023

出　　处：《中国生化药物杂志》2003年第2期76-78,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的观察干酪菌发酵产物对小鼠小肠推进功能的影响。方法采用小鼠小肠推进实验观察经胃给予干酪菌发酵产物前后小肠推进百分比的变化以及腹腔注射几种受体阻断剂后对其药效的影响。结果干酪菌发酵产物 ( 1 50、30 0、6 0 0mg kg)能提高小鼠小肠推进百分比 ,且呈剂量 效应依赖关系 ;苯海拉明 ( 1 0mg kg)能抑制其对小肠运动的促进作用 ;阿托品 ( 1 0mg kg)能部分对抗其药效。结论干酪菌发酵产物能提高小鼠小肠推进功能 ;其作用途径与H1 受体有关 ,可能与M受体有间接关系。Purpose To study the effect and its mechanism of zymotic fluid of Polypor Laetiporus (ZPL) on the intestinal propulsive movement in conscious mice.MethodsThe intestinal propulsive movements were observed with different doses of ZPL. We also detected its effect before and after administration of some antagonists (phentalamine, propranolol, diphenhydramine, and atropine).ResultsZPL (150 mg/kg) increased markedly the propulsive movement in a dose dependent manner, it remained unchanged after the administration of phentolamine or propranolol; ZPL′s excitement responses were abolished by diphenhydramine, partly inhibited by atropine.ConclusionZPL could significantly augment the intestinal propulsive movement with dose dependent effect,and the effects of ZPL might mediate through histamine pathway or indirectly through M receptor.

关 键 词：干酪菌发酵产物 小肠推进百分比 H1受体 M受体 

分 类 号：R961[医药卫生—药理学] R975[医药卫生—药学]