注射用甲泼尼龙琥珀酸钠细菌内毒素检查研究  

Application of the Bacterial endotoxins test For Methylprednisolone Sodium Succinate for Injection

作　　者：孙淑莲[1] 苑庆华[1] 叶志[1] 唐元泰[1] 

机构地区：[1]天津市药品检验所,天津300070

出　　处：《天津药学》2003年第2期23-25,共3页Tianjin Pharmacy

摘　　要：目的 :对注射用甲泼尼龙琥珀酸钠进行细菌内毒素检查研究 ,建立检测注射用甲泼尼龙琥珀酸钠中内毒素试验方法。方法 :采用中国药典 2 0 0 0年版附录细菌内毒素检查法。结果 :注射用甲泼尼龙琥珀酸钠在药液稀释浓度1.5 mg/ ml以下时 ,与 TAL试剂反应无干扰因素影响。结论Objective: Application of the bacterial endotoxins test for Methylprednisolone Sodium Succinate for Injection was studied. Method: According to the bacterial endotoxins test and eliminated interfere factors approved by Chinese pharmacopoeia 2000 edition. Results: Endotoxin added to Methylprednisolone Sodium Succinate for Injection was recovered in quantitative manner showing neither inhibition nor enhancement in diluted solution concentration 1.5 mg/ml Conclusion: These results suggested that the bacterial endotoxins test was suitable for the detection endotoxin in Methylprednisolone Sodium Succinate for Injection.

关 键 词：甲泼尼龙琥珀酸钠 细菌内毒素 检查 试验 糖皮质激素类药物 

分 类 号：R977.11[医药卫生—药品] R927.1[医药卫生—药学]