超声激活血卟啉杀伤癌细胞的扫描电镜观察  

The scanning electron microscope observation of two kinds cancer cells treated by ultrasound irritating HpD

作　　者：李萌[1] 刘全宏[1] 齐浩[1] 张金选[1] 张坤[1] 王攀[1] 

机构地区：[1]陕西师范大学生命科学学院,陕西西安710062

出　　处：《西北大学学报（自然科学版）》2003年第2期223-225,共3页Journal of Northwest University（Natural Science Edition）

基　　金：国家自然科学基金资助项目(39870240);教育部"高等学校骨干教师资助计划"项目(2000)

摘　　要：利用频率为2MHz,强度为0.9W/cm2的超声(Ultrasound,US)激活血卟啉(Hematoporphyrinderivatives,HpD)对在体的腹水型艾氏腹水瘤细胞(EhrlichAscitesTumor,EAT)和S180(Sarcoma180,S180)细胞进行抑癌作用研究。通过扫描电子显微镜观察处理后细胞形态的变化,结果表明:超声激活血卟啉对艾氏腹水瘤细胞和S180细胞均有明显的杀伤效果,且通过对损伤不同形态的比较,得出S180细胞膜较艾氏腹水瘤细胞膜对于声动力疗法(SonodynamicTherapy,SDT)更为敏感。The antitumor effects of hematoporphyrin derivative (HpD)activated by ultrasound (US)was studied on Sarcoma180(S180)and Ehrlich ascites tumor(EAT)cells through scanning electronic microscope.The results indicated that the synergia of US and HpD had remarkable antitumor effects on ascitic S180 and EAT cells.At the same time,the comparison between two ascitic tumor cells′ images of injured membranae illustrated the S180 cells was more sensitive than EAT cells to HpD activated by US.

关 键 词：癌细胞 血卟啉 抑癌作用 超声 声动力疗法 艾氏腹水瘤 细胞形态 扫描电镜观察 

分 类 号：R735.5[医药卫生—肿瘤] R454.3[医药卫生—临床医学]