宫颈癌刮片细胞CEA免疫细胞化学研究  

Study on CEA Immunocytochemistry in the Cell Specimen Scraped from the Cervical Carcinoma

作　　者：宗安民[1] 史学义[1] 孟爱民[1] 吴景兰[1] 王克聪[2] 王福丰 张风芝 

机构地区：[1]河南医科大学组织胚胎学教研室 [2]河南医科大学三附院妇产科 [3]河医大一附院 [4]郑州国棉五厂职工医院

出　　处：《河南肿瘤学杂志》1992年第3期1-3,共3页Henan Journal of Oncology

摘　　要：本文应用SPA-HRP(辣根过氧化物酶标记的金黄色葡萄球菌蛋白A)免疫组织化学技术对14例宫颈癌和6例非宫颈癌的刮片细胞进行了CEA免疫反应性(IR)观察。结果见97％的癌细胞呈CEA-IR,且反应较强;大多数非典型增生细胞亦呈CEA-IR,并见有少数正常宫颈上皮细胞星弱CEA—IR。以上三者的CEA-IR有显著性差异。文中讨论了宫颈刮片细胞CEA免疫细胞化学检测对宫颈癌早期诊断的辅助价值及其对特异CEA抗体导向的局部抗宫颈癌治疗的意义。Using SPA-HRP immunohistochemical technique for CEA detection the cell specimen scraped from 14 cases of cervical carcinoma and 6 cases of nonmalignant cervix were observed in comparasion. It was found that 97% of the cancer cells showed CEA immunoreactivity with stronger intensity; most dysplasia cells showed CEA immunoreactivity also and a weak CEA immunoreactivity was present in a few epithelial cells in normal cervix. Among them there was a significant difference in CEA immunoreactivity. In this paper the significance of CEA immunochemical detection from cervical scraping used as an adjunct to early diagnosis of cervical carcinoma and as a backing for local therapy with specific CEA antibody against the cervical cancer cells was discussed.

关 键 词：癌胚抗原 免疫细胞化学 子宫颈肿瘤 

分 类 号：R737.330.3[医药卫生—肿瘤]