非均匀恒磁场对急性低压缺氧小鼠学习记忆障碍的预防作用  

Preventive effect of uneven constant magnetic field on learning and memory impairment induced by acute hypobaric hypoxia in mice

作　　者：沙建慧[1] 郭宝军[2] 沈楠[3] 黄晶波[2] 孙新奇[4] 朱芙蓉[5] 

机构地区：[1]第四军医大学吉林军医学院生理教研室,吉林市132013 [2]第四军医大学吉林军医学院病理教研室,吉林市132013 [3]第四军医大学吉林军医学院药理教研室,吉林市132013 [4]第四军医大学吉林军医学院航医教研室,吉林市132013 [5]第四军医大学吉林军医学院附属医院理疗科,吉林市132013

出　　处：《中华航空航天医学杂志》2003年第1期31-34,F004,共5页Chinese Journal of Aerospace Medicine

摘　　要：目的　探讨非均匀恒磁场N极、S极对急性低压缺氧引起的学习记忆障碍的预防作用　方法　动物分为对照组、缺氧组、磁场N极 +缺氧组和磁场S极 +缺氧组。用避暗实验法和自主活动法 ,分别观察了非均匀恒磁场N极、S极对急性低压缺氧引起的学习记忆障碍的影响。用电镜观察急性低压缺氧及非均匀恒磁场N极、S极作用后 ,脑皮质细胞形态学改变。　结果　①避暗实验表明 :磁场N极 +缺氧组、磁场S极 +缺氧组与缺氧组相比 ,记忆成绩M值显著减少 (P <0 .0 1或P <0 .0 5 ) ,潜伏期显著延长 (P <0 .0 1或P <0 .0 5 )。磁场N极 +缺氧组与磁场S极 +缺氧组相比 ,前者潜伏期较长 (P <0 .0 5 )。②缺氧组与其它 3组相比 ,自主活动明显减少 (P <0 .0 1)。③非均匀恒磁场可缓解缺氧导致神经元的核变形以及核膜结构不光滑等现象。　结论　非均匀恒磁场对缺氧引起的障碍有预防性作用 ,可改善由缺氧造成的记忆功能损害 ,并减轻脑神经元的病理变化 ,N极作用更为明显。Objective To investigate preventive effect of uneven constant magnetic field on learning and memory impairment induced by hypobaric hypoxia in mice. Method Seventy two mice were divided into control group, hypoxia group(8 000 m,30 min), magnetic field pole N(15 days)+hypoxia group and magnetic field pole S(15 days)+ hypoxia group. The step through test and independent activity were used to observe effect of uneven constant magnetic field pole N and S on learning and memory impairment induced by hypobaric hypoxia . The histomorphological changes of brain cortex were observed by electron microscope Results ①The results of step through test indicated that the mistakes of magnetic field pole N+ hypoxia group and magnetic field pole S+ hypoxia group were less than that of hypoxia group( P<0.01,P<0.05 ) and the escape latency was longer than that of hypoxia group( P<0.01,P<0.05 ). Compared with the magnetic field pole S+ hypoxia group, the escape latency of the magnetic field pole N + hypoxia group was longer( P <0.05).②The independent activity of hypoxia group rats was significantly less than that of other 3 groups ( P <0.01).③Uneven constant magnetic field could alleviate the deformation of neuronal nucleus and change of nuclear membrane structure induced by hypoxia. Conclusions Staying in constant magnetic field especially pole N possesses preventive effect against impairment of brain induced by acute hypoxia.

关 键 词：低氧 学习 记忆 电磁场 显微镜检查 电子 

分 类 号：R363[医药卫生—病理学]