尼莫地平对顽固性癫痫的疗效及其抗氧化作用的研究  

Clinical study of nimodipine on intractable epilepsy patients and it's antioxcidant role

作　　者：谢安木[1] 梁迎春[1] 王玉凯[1] 焦念宝[1] 耿家贵[1] 陆寅[1] 

机构地区：[1]泰山医学院第一教学医院神经内科,山东泰安271000

出　　处：《泰山医学院学报》2003年第1期54-56,共3页Journal of Taishan Medical College

摘　　要：目的　探讨尼莫地平对顽固性癫痫病人的脑保护作用。方法　 30例顽固性癫痫病人 ,在服用原抗癫痫药的基础上 ,用微量输液泵静脉滴入尼莫地平注射液连用 7天 ,然后用尼莫地平维持治疗至三个月 ,进行治疗前后疗效对比。并测定治疗前后血中SOD、GSH PX、MDA的水平。结果　尼莫地平配合抗癫痫药物治疗顽固性癫痫与治疗前相比效果显著 ,而且副作用较少。治疗后SOD、GSH PX明显增高和MDA明显下降。结论　尼莫地平对顽固性癫痫有一定脑保护作用 。Objective: To study the brain protection of nimodipine in intractable epilepsy patients Methods: Thirty patients were selected for nimodipine injection by vein with micro injection pump once a day, for seven days, followed by nimodipine tablet treatment for 3 months Effects before and after treatment were compared And the levels of SOD, MDA and GSH PX in the patients' serum before and after treatment were also measured Results: Nimodipine combined with anti seizure drugs had a remarkable effect on intractable epilepsy The levels of SOD and GSH PX increased significantly while the levels of MDA decreased obviously after nimodipine treatment Conclusion: It is suggested that nimodipine plays a role of brain protection in intractable epilepsy This may be relate to its anti free radicle effect in addition to the inhibition of Ca 2+ inflow

关 键 词：癫痫 药物治疗 抗氧化 

分 类 号：R742.1[医药卫生—神经病学与精神病学]