金裕星注射液稳定性及其有效期预测  

Stability study of Jinyu Star injection and prediction of its expiry term

作　　者：董亚琳[1] 董海燕[1] 姚鸿萍[1] 张华安[1] 

机构地区：[1]西安交通大学第一医院,西安710061

出　　处：《中国现代应用药学》2003年第2期163-164,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的　考察金裕星注射液稳定性 ,并预测其室温贮存有效期。方法　紫外分光光度法测定金裕星注射液含量 ,用初匀速法预测其有效期。结果　金裕星注射液在 5～ 1 0 μg·mL- 1 范围内呈良好线形关系 (r =0 .9999) ,平均回收率 1 0 0 .0 7% ,RSD0 .1 2 %。结论　初匀速法预测金裕星注射液有效期简便、迅速。金裕星注射液稳定性好 ,室温 2 5℃贮存期 4 .1 9年。OBJECTIVE To survey the stability of Jinyu Star injection at 25℃ and predict its expiry term. METHOD Jinyu Star injection was determined by UV spectrophotometry, its expiry date was predicted by an initial average rate method.RESULTS The linear range of Jinyu Star injection was 5～10μg·mL -1 (r=0.9999).The average recovery of Jinyu Star injection was 100.07%, RSD 1.2%.CONCLUSION Initial average rate method is convenient and rapid. Stability of Jinyu Star injection is good, expiry of term predicted at 25℃ is 4.19 years. Initial average rate method provides a scientific basis for clinical application.

关 键 词：金裕星注射液 抗菌药物 紫外分光光度法 初匀速法 有效期 稳定性 

分 类 号：R978.1[医药卫生—药品] R927.11[医药卫生—药学]