湖南汉族人群HLA-DRB1位点等位基因多态性与鼻咽癌的相关性研究  

The Correlation between HLA-DRB1 Allelic Polymorphisms and Nasopharyngeal Carcinoma in Han People in Hunan Province

作　　者：王志鹏[1] 郭实士[1] 余平[1] 

机构地区：[1]中南大学湘雅医学院免疫研究室,中国湖南长沙410078

出　　处：《实用预防医学》2003年第2期129-131,共3页Practical Preventive Medicine

基　　金：国家自然科学基金 ( 392 70 6 6 );CMB基金

摘　　要：目的　探讨湖南汉族人群HLA -DRB1位点基因多态性与鼻咽癌遗传易感性之间关系。　方法　用多聚酶链反应 -序列特异性寡核苷酸探针斑点杂交方法 ,对 93例湖南汉族鼻咽癌患者与 93例健康对照作HLA -DRB1位点基因分型 ,采用 χ2 检验比较两组各位点等位基因频率分布差异。　结果　鼻咽癌组DRB1 0 80 1较对照组高 (χ2 =4.2 2 ,P =0 .0 4 ,RR =1 .95) ,DRB1 1 1 0 1较对照组降低 (χ2 =5 .2 8,p =0 .0 2 ,RR =0 .33) ,但P值经Bonferoni校正后 ,差异无显著性(Pc >0 .0 5)。　结论　本研究结果未能证实HLAObjective To investigate whether the polymorphisms of HLA-DRB1 alleles were associated with nasopharyngeal carcinoma(NPC). Methods 93 NPC patients and 93 normal individuals of Han people in Hunan province were genotyped for HLA-DRB1 locus by PCR/SSO technique. The frequency of allele in NPC group was compared with that in normal group by chi-square test. Result The frequency of DRB1 *0801 in NPC group was much higher than that in normal group(RR=1.95,χ 2=4.221,P=0.04), but DRB1 *1101 was significantly lower in the former than that in the latter(RR=0.33,χ 2=5.284,P=0.022) ?There was no significant difference after Bonferoni correction (Pc>0.05). Conclusion The results could not prove there was significant correlation between nasopharyngeal carcinoma and HLA-DRB1 locus.

关 键 词：鼻咽癌 HLA-DRB1 等位基因多态性 多聚酶链反应-序列特异性寡核苷酸探针 

分 类 号：R739.63[医药卫生—肿瘤]