无色素性恶性黑色素瘤HMB45和S—100蛋白的表达  

The Expressions of HMB45,S-100 in Amelanotic Malignant Melanoma

作　　者：唐四元[1] 周建华[1] 蒋海鹰[1] 颜亚晖[1] 傅春燕[1] 

机构地区：[1]中南大学湘雅医学院,中国湖南长沙410078

出　　处：《实用预防医学》2003年第2期144-145,共2页Practical Preventive Medicine

摘　　要：目的　探讨无色素性恶性黑色素瘤中HMB45和S - 1 0 0的表达及其意义。　方法　应用HMB45 ,S - 1 0 0 ,Vimentin,NSE ,Keratin ,LCA ,HHF45系列抗体对 31例无色素性恶性黑色素瘤进行SP法免疫组织化学方法检测和分析。　结果　 31例瘤组织中HMB45阳性率 96 .8% (30 / 31 ) ,S - 1 0 0 80 .6 % (2 5/ 31 ) ,Vimentin1 0 0 % (31 / 31 ) ,而NSE ,Keratin,LCA ,HHF35均呈阴性。　结论　无色素型恶性黑色素瘤组织中HMB45阳性表达率高 。Objective To explore the expressions of HMB45 and S-100 as well as their significances in amelanotic malignant melanoma (AMM). Methods A series of antibodies including HMB45, S-100, Vimentin, NSE,Keratin, LCA, HHF35 were used on paraffin sections in 31 cases of AMM by SP immunohistochemical methods. Result Positive rates of HMB45, S-100, Vimentin staining were 96.8%(30/31), 80.6%(25/31), 100%(31/31) respectively, while none showed immunoreactivity with NSE, Keratin, LCA, HHF35. Conclusion HMB45 may be a specific marker for AMM. Inmunohistochemistry is a good help for its confirmed diagnosis and differentiation.

关 键 词：黑色素瘤 免疫组化 诊断 

分 类 号：R73[医药卫生—肿瘤]