新疆汉、维族妇女乳腺良恶性病变中p53、IGF-IR及PCNA的异常改变及其病理学意义  

Abnromal expression of p53,IGF-IR and PCNA in benign and malignant breast lesions of Han,Uygur woman in Xinjiang

作　　者：朱晓丽[1] 孙振柱[2] 陈朝伦[1] 

机构地区：[1]新疆医科大学病理教研室,新疆乌鲁木齐830054 [2]新疆自治区人民医院病理科,新疆乌鲁木齐830000

出　　处：《中国癌症杂志》2003年第2期144-146,149,共4页China Oncology

摘　　要：目的 :检测汉族、维吾尔族 (简称汉、维族 )妇女乳腺良恶性病变中p53、IGF IR、PCNA的异常表达是否存在差异 ,并讨论其意义。方法 :应用免疫组化 (LSAB法 )检测 56例乳腺癌、38例乳腺病、2 5例乳腺导管乳头状瘤组织。结果 :p53、PCNA在癌组织中的阳性表达率 (58 9% ,98 2 % )明显高于良性病变 (4%～ 5 3 % ,76 %～78 9% ) (P <0 0 5) ;IGF IR在乳腺癌中的阳性表达率 (1 0 0 % )高于乳腺导管乳头状瘤 (88% ) (P <0 0 5) ;p53蛋白在汉族妇女乳腺癌中的表达 (67 6 % )高于维族妇女 (42 1 % ) ,但差异无统计学意义。p53蛋白、IGF IR、PCNA的阳性表达与乳腺癌患者的组织学分级、淋巴结转移状态无明显关系。结论 :1 p53、IGF IR和PCNA的过度表达可能参与乳腺良性病变恶性转化及乳腺癌的发生 ;2 p53突变在汉族妇女乳腺癌发生中起重要作用 。Purpose:Detection of p53,IGF IR and PCNA abnormal expression in tumor tissues of Han, Uygur patients with breast benign and malignant lesions may offer more important molecular biologic data of human breast carcinogenesis. Methods:p53?IGF IR and PCNA in 56 breast cancer,38 adenosis, 25 papilloma tissues were dectected by immunohistochemistry (LSAB). Results:The postive frequency of p53 protein, PCNA in breast cancer (58 9%, 98.2%) was found to be notably higher than in benign lesions (4%～5.3%,76%～78.9%) respectively ( P <0 05) The IGF IR in both cancer and adenosis (100%) were moderately higher than in papilloma (88%). Over expression of p53 protein in Han patients with breast cancer was higher(67.6%) than in Uygur patients (42.1%) but no statistic significance was found. No statistic significance in positive rate of p53, IGF IR and PCNA on histologic grading, nodal status of cancer patients was found. Conclusions:①Overexpression of p53 protein,IGF IR and PCNA with a high frequency may be involved in the malignant transformation and carcinogenesis from breast benign lesions; ②p53 mutation may play an important role in breast carcinogenosis of Han women;but other oncogenes and tumor suppressor genes,other than p53,may be implicated in the critical regulation of breast carcinogenesis in Uygur people.

关 键 词：新疆 维族 妇女 乳腺良恶性病变 P53 IGF-IR PCNA 病理 汉族 

分 类 号：R737.9[医药卫生—肿瘤]