药物从多孔骨架聚合物系统中控制释放的动力学模型  

MATHEMATICAL MODEL OF DRUG RELEASE FROM POROUS POLYMER

作　　者：李凌冰[1] 谭业帮[2] 

机构地区：[1]山东大学药学院药剂教研室,济南250012 [2]山东大学化学院,济南250100

出　　处：《中国生物医学工程学报》2003年第2期120-125,119,共7页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目 (2 990 40 0 3 )

摘　　要：以组分的连续性方程为基础 ,建立了药物从多孔骨架聚合物系统中释放的数学模型。在模型中引入相对渗透速度来刻画药物释放过程中不同机理的影响 ,并用摄动方法对方程进行了求解。对所得结果进行了分析 ,特别对药物溶出机制控制的恒速释药现象进行了解释。A mathematical model describing the drug release from porous polymer was established by using the species continuity equation. The relative permeating rate was introduced to describe the effects of the different physical processes. An asymptotic solution has been obtained by using the perturbation theory. The whole process of the drug released from porous polymer was analyzed, especially the process controlled by drug dissolution.

关 键 词：连续性方程 多孔骨架聚合物 数学模型 摄动方法 

分 类 号：R318.01[医药卫生—生物医学工程]