应用单克隆抗体检测肺癌病人外周血中T细胞亚群  

Investigation on T Lymphocyte Subsets of Peripheral Blood of Patients with Primary Pulmonary Carcinoma with Mouse Monoclonal Antibody

作　　者：朱建思[1] 周建国[1] 何志藩[1] 谢金魁[2] 庄英帜[2] 

机构地区：[1]衡阳医学院实验肿瘤研究室 [2]衡阳医学院附一院肿瘤内科

出　　处：《衡阳医学院学报》1992年第3期234-237,共4页

摘　　要：本文应用单克隆抗体检测33例原发性肺癌病人治疗前后外周血中T淋巴细胞亚群变化。结果提示:肺癌病人外周血中T细胞亚群明显有别于正常人,主要表现为T_H细胞降低和T_S细胞升高以及T_H/T_S比值明显倒置。短期观察结果表明,肺癌病人外周血中T_S细胞持续升高和T_H/T_S比值持续降低者,预后不良。临床检测T细胞亚群变化及它们的动态变化可作为判断宿主抗肿瘤免疫功能状态、病情发展和预后的敏感指标。In this study, The changes of T lymphocyte subsets of peripheral blood in 33 cases with primary pulmonary Carcinoma before and after treatment were investigated with mouse monoclonal antibody against human T lymphocyte subsets. Results showed that there was remarkable difference between T lymphocyte subsets of peripheral blood of the patients withe lung cancer and normal human. It was shown that T_H cells fell, Ts cell rose and T_H/T_S ratio became inverse. The short—time observation result proved that patients with lung cancer whose T_S ceils ontinuously rose and T_H/T_S ratio decreased continuously in their peripheral blood had an unhealthy prognosis. Clinically, examination of T cell subsets and their dynamic change in patients with tumor may be uesed as a sensitive criterion reflecting the host immunity against tumor, and the development and prognosis of the disease.

关 键 词：单克隆抗体 T细胞亚群 肺肿瘤 

分 类 号：R734.204[医药卫生—肿瘤]