面神经损伤致面运动神经元死亡的实验研究  

A Study on Facial Motoneuron Death Following Facial Nerve Injury.

作　　者：魏海刚[1] 李蜀光[1] 邱雅 许彪[3] 

机构地区：[1]佛山市第二人民医院颌面-耳鼻咽喉外科,广东佛山528000 [2]云南省计划生育科学研究所 [3]昆明医学院第一附属医院口腔颌面外科

出　　处：《广东牙病防治》2003年第2期86-88,T001,共4页Journal of Dental Prevention and Treatment

摘　　要：目的　研究面神经低位切断伤及压榨伤后 ,大鼠面运动神经元的形态学改变及其死亡的时间进程。方法　手术制作大鼠右侧面神经的低位切断伤、压榨伤模型 ,左侧为正常对照侧。用HE和甲苯胺蓝染色技术观测面运动神经元死亡情况及其形态学变化。结果　面神经切断伤及压榨伤均可引起面运动神经元死亡 ,且于伤后 4周时达到高峰 (切断伤组死亡率 5 1.19%± 9.5 7% ,压榨伤组死亡率 2 7.90 %± 4 .6 8% ) ;除损伤后第一天外 ,损伤后各时间点切断伤组神经元死亡数目明显较压榨伤组多 (P <0 .0 1)。结论　面神经切断伤及压榨伤均可引起面运动神经元死亡 ,死亡数目与损伤形式有关。对重度的神经损伤 ,临床神经修复应争取在损伤后Objective To investigate morphological changes of facial motoneuron and its death course following facial nerve distal transection or crush in rats. Methods The right facial nerve was performed distal transection or crush, and the left side as normal control. The morphology and the death course of motoneurons were observed under light microscope. Results The axons suffered from transection or crush resulted in death of the facial motoneurons. The motoneurons' loss peaked 28 days after injuries(the death rate of transection group 51.19%±9.57% vs. 27.90%±4.68% for crush group). The number of dead motoneurons in the distal transection group was more than that in the crush group (P<0.01) . Conclusions Different facial nerve injuries result in death of facial motoneurons. The motoneuron death was relative with the patterns of injuries. Clinical nerve repair should be performed as early as possible in four weeks after the transection.

关 键 词：面神经损伤 面运动神经元 实验研究 细胞死亡 

分 类 号：R745.12[医药卫生—神经病学与精神病学]