IL-6基因多态性与汉族人群慢性牙周炎敏感性关系的研究  

Association of IL-6 Gene Polymorphisms with the Susceptibility to Chronic Periodontitis of Chinese Han Nationality

作　　者：孙江[1] 马文波[1] 章锦才[2] 庞若愚[2] 张蕴惠[1] 

机构地区：[1]四川大学华西口腔医学院,四川成都610041 [2]广东省口腔医院

出　　处：《广东牙病防治》2003年第2期89-92,共4页Journal of Dental Prevention and Treatment

摘　　要：目的　探讨IL 6基因多态性与汉族人群慢性牙周炎敏感性的关系。方法　收集了汉族轻、中、重度慢性牙周炎共 16 6例和 80例健康对照的颊粘膜拭子 ,以Chelex 10 0法提取DNA ,用PCR -RFLP法检测IL 6 174的多态性 ,比较患者和对照组中基因型分布和等位基因频率的差异。结果　轻、中、重度慢性牙周炎患者中IL 6 174位点的基因型分布在患者组和对照组间无明显差别 ,汉族中IL 6 174位点等位基因C的频率极少 ,明显低于高加索人。结论　IL 6Objective There are evidences demonstrating the roles of IL?6 in the pathogenesis of periodontitis. This study was performed to investigate association of IL?6 gene polymorphisms with the susceptibility to chronic periodontitis of Chinese Han nationality. Methods Buccal swabs from 166 patients with severe, moderate and mild chronic periodontitis respectively and 80 matched healthy control individuals were collected. DNA was extracted using Chelex 100 method. IL?6 ?174 polymorphisms were tested with PCR?RFLP. The distribution of genotype and allele frequencies in the patient and control groups were analyzed. Results It was showed that no significant differences in distribution of genotype of IL?6?174 were observed among patients and controls. The IL?6?174 allele C is rare in Han Nationality. Conclusion IL?6?174 polymorphisms were not associated with the susceptibility to chronic periodontitis of Chinese Han nationality.

关 键 词：慢性牙周炎 IL-6 疾病敏感性 基因多态性 

分 类 号：R781.42[医药卫生—口腔医学]