从Genomics,Proteomics到Cytomics,还是从Cytometry到Cytomics  

From Genomics,Proteomics to Cytomics,or from Cytometry to Cytomics

作　　者：龚建平[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肿瘤研究所,湖北武汉430030

出　　处：《癌症》2003年第5期449-451,共3页Chinese Journal of Cancer

摘　　要：Cytomics是一个特殊名词,她将cyto-与-omics连在一起,代表着一个崭新的领域。Cyto-主要来自分析细胞学(analyticalcytology或cytometry),而-omics主要来自蛋白质组学(proteomics)及其决定者基因组学(genomics)。经过三十余年的发展,分析细胞学可以通过分子探针将异质性的或混杂的细胞群体分为不同的细胞组份(cytomes),而基因组学和蛋白质组学的技术已能鉴定出某一物种的整套基因组和蛋白质组。因此,我们认为,细胞组学的任务是分离细胞组,并在基因组和蛋白质组层面确定其赖以存在和转变的分子基础。细胞组学的实施需要两大系列技术,一是细胞组分离技术,二是分离后再分析技术。这些技术的发展将使我们最终理解基因组并利用之,也必将拓展出更新的领域。Cytomics, an ad hoc term, represents a new field which connects cyto with omics. The cyto arises from analytical cytology or cytometry, which has developed for more than three decades and includes a serial of quantitative technology which can separate the heterogenetic cell populations into different cytomes by molecular probes. The omics comes from proteomics which is determined by genomics. Therefore, cytomics is to separate the cytomes by cytometry technology and identify their proteomes controlled by genome or special genes. Cytomics project consists of two parts of technology, one is separation of cytomes and another is post sorting analysis. Development of cytomics related technology would help us to understand molecular basis of different cytomes and the transition between them, to gradually grasp the details of genomics, and to know of how to apply them for clinical work. Thus, a new horizon will appear.

关 键 词：Genomics Proteomics CYTOMICS CYTOMETRY CYTOMICS 细胞组学 基因组学 蛋白质组学 流式细胞术 

分 类 号：Q78[生物学—分子生物学]