肿瘤转移抑制基因KAI1在大肠癌进展中的作用  

Role of Tumor Metastasis Suppressor Gene KAI1 in Development of Colorectal Cancer

作　　者：杨景[1] 柳凤轩[1] 阎晓初[1] 贺光友[1] 刘丽梅[1] 

机构地区：[1]第三军医大学附属西南医院病理研究所,重庆400038

出　　处：《癌症》2003年第5期533-536,共4页Chinese Journal of Cancer

摘　　要：背景与目的:对于肿瘤转移抑制基因KAI1在大肠癌中的表达及其与病理分期的关系存有争议,关于它与肿瘤患者预后的报道仍然较少。本研究旨在探讨KAI1在大肠癌进展中的作用及其在预后判断中的价值。方法:采用免疫组化法检测91例大肠癌原发灶及25例淋巴结转移灶中KAI1表达。结果:KAI1在大肠癌原发灶中阳性表达54例(59.3%),弱阳性22例(24.2%),阴性15例(16.5%)。KAI1在低分化、有淋巴结转移、远处脏器转移肿瘤中表达显著降低(P<0.01);5年生存者的KAI1阳性表达率(67.14%)显著高于5年内死亡者(33.33%)(P<0.05);KAI1表达阳性、弱阳性以及阴性患者的5年生存率依次为87.04%、63.34%、60.00%,呈下降趋势(P<0.05),淋巴结转移灶的KAI1表达显著低于原发灶(P<0.05)。结论:KAI1的异常表达可能参与了大肠癌的恶性进展。检测KAI1的表达对判断肿瘤的分化、淋巴结转移和远处转移及大肠癌患者预后有一定的参考价值。BACKGROUND &OBJECTIVE: The study of tumor metastasis suppressor gene KAI1 in colorectal cancer (CRC) is limited nowadays. There are some controversies about the expression of KAI1 and its relationship with pathologic classification of CRC, and up today, the reports of the correlation between KAI1 and the prognosis of CRC still be few. This study was designed to investigate the role of KAI1 in development of CRC and its value in predicting the prognosis of CRC. METHODS: The expression of KAI1 in 91 cases of primary CRC and 25 cases of lymph node metastases were determined using immunohistochemistry. RESULTS: The positive cases of KAI1 in primary CRC were 54 (59.3%), the weak positive cases were 22 (24.2%), the negative cases were 15 (16.5%).KAI1 expression reduced significantly in the cases with low differentiation,lymph node metastasis and distant metastatic tumor(P< 0.01). The positive expression rate of KAI1 in the patients who survived more than 5 years (67.14%) was higher than that in the patients who survived less than 5 years (33.33%)(P< 0.05). The 5 year survival rates of the patients with positive, weak positive, and negative expression of KAI1 decreased in turn (87.04%, 63.34%, 60.00%;P< 0.05). KAI1 expression in lymph node metastases was lower than that in primary locus(P< 0.05). CONCLUSION: The abnormal expression of KAI1 participates in malignant progression of CRC. Detecting the expression of KAI1 probably possesses clinical significance in evaluating the differentiation, lymph node metastasis,and distant metastasis of CRC, and predicting the prognosis of CRC.

关 键 词：肿瘤 转移抑制基因 KAl1 大肠癌 作用 

分 类 号：R735.34[医药卫生—肿瘤]