氟尿嘧啶持续输注为主的ELFP方案治疗晚期胃癌的临床观察  

Clinical investigation of chemotherapy with CF/5-Fu,DDP, Vp-16 in patients with advanced gastric adeno-carcinoma

作　　者：孙艳丽[1] 陈武[1] 王立波[1] 冯立艳[1] 

机构地区：[1]吉林省肿瘤医院化疗科,长春130012

出　　处：《中国肿瘤临床与康复》2003年第2期139-140,共2页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的 观察亚叶酸钙(CF)、氟尿嘧啶(5-Fu)持续输注、足叶乙甙(Vp-16)、顺铂(DDP)组成的ELFP方案治疗晚期胃癌的疗效和毒副作用。方法 已经病理证实的晚期胃癌41例,采用DDP30 mg静滴,第1～4天;Vp-16 100 mg静滴,第1～5天;CF 200 mg/m2静脉滴注2 h,第1～5天;5-Fu375 mg/m2静脉持续滴注,于CF滴注一半时采用锁骨下深静脉穿刺滴入,第1～5天。21 d为一周期。结果 41例患者中,CR率为17.1％(7/41),PR率为41.5％(17/41),总有效率(RR)58.5％(24/41)。不良反应:白细胞减少Ⅰ～Ⅱ度发生率为70.7％,Ⅲ度仅为4.9％;血小板减少发生率31.7％,均为Ⅰ～Ⅱ度;胃肠道反应发生率为39％;口腔黏膜炎发生率17.1％。结论 氟尿嘧啶持续输注为主的ELFP方案治疗晚期胃癌疗效较高,不良反应轻,患者可耐受。Objective To assess the antitumor efficacy and tolerance of the combination of CF /5-Fu, DDP and Vp-16 in advanced gastric adenocarcinoma patients. Methods Forty-one patients with advanced gastric ade-nocarcinoma were treated with iv infusion of DDP 30 mg/day for 4 days, Vp-16 100 rag/day for 5 days, CF 200 mg/ m2 /day for 5 days,as well as 5-Fu 375 mg/m2 /day.5-Fu was given through a catheter in the subclavin vine Ihour after CF infusion. The above scheme was repeated every three weeks. Results Of 41 cases of gastric adenocarcinoma 7 achieved CR and 17 PR,and the response rate (CR+ PR) was 58.5% .The main toxic side-effects included leukopenia,alimentary tract reaction and mucositis. Leukopenia was observed in 75.6% of the patients, but grade III of it was only found in 4.9 % . Grade I - II thrombocytopenia occourred in 31.7 % of patients. The alimentary tract was 39% and mucositis 17.1 % . Conclusion ELFP regimen has relatively high response rate in patients with advanced gastric adenocarcinoma.The toxicity is slight and can be well tolerated.

关 键 词：氟尿嘧啶 持续输注 ELFP方案 治疗 晚期 胃癌 亚叶酸钙 足叶乙甙 顺铂 疗效 毒副作用 

分 类 号：R735.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]