米索前列醇阴道给药用于宫颈不成熟足月引产效果分析  

Effects of Misoprostol in the Induction in Pregnant Women with Unfavorable Cervix

作　　者：李立安[1] 王湘[1] 卢彦平[1] 

机构地区：[1]中国人民解放军总医院妇产科,北京100853

出　　处：《解放军药学学报》2003年第2期94-96,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的　比较米索前列醇阴道给药和缩宫素静脉点滴用于宫颈未成熟足月产妇促宫颈成熟和引产的有效性及安全性。方法　 6 0例孕 37～ 4 2周的正常产妇随机分为 2组 ,一组为米索前列醇阴道给药 ,2 5 μg/4h ,每日总剂量不超过 10 0 μg(共 30例 )。另一组给予 0 .5U %缩宫素静脉点滴。结果　两组产妇在年龄、身高、体重、孕周、宫颈评分没有统计学差异。米索前列醇组引产成功率高于缩宫素组。米索前列醇组发动临产时间、总产程短于缩宫素组。结论　小剂量米索前列醇引产是安全有效的 ,可以提高宫颈评分 。Aim To compare the safety and effect of intravaginal misoprostol tablets with that of intravenous oxytocin for ripening the cervix and induction in women with unfavorable cervices.Methods 60 pregnant women with 37～41w pregnancy were selected and randomly divided into misoprostol and oxytocin groups.One group received misoprostol intravaginally every 4 hours with a dose of 1/8 tab (≌25μg) and no more than ≌100μg in 24h.Another group was given 0.5U% oxytocin intravenously.Results There were no statistically significant differences in age,height,body weight,pregnancy week and uterine cervical ripening between the two groups of women inducting of labor.The rate of successful inducting of labor was higher and the time from administration of the drug to the onset of regular contraction activity of the uterus and delivery of an infant was shorter in the group of patients receiving misoprostol than oxytocin infusion.Conclusion Low dose misoprostol can promote cervical ripening and may be effective and safe in induction.

关 键 词：米索前列醇 阴道给药 宫颈不成熟 足月 引产 产妇 缩宫素 

分 类 号：R719.31[医药卫生—妇产科学]