The Value of the Measurement of Urinary Hyaluronic Acid Levels for the Diagnosis of Bladder Cancer  

尿透明质酸含量诊断膀胱癌的临床研究(英文)

作　　者：杨为民[1] 蔡建良[1] 陈志强[1] 周健[1] 

机构地区：[1]武汉华中科技大学同济医学院附属同济医院,430030

出　　处：《The Chinese-German Journal of Clinical Oncology》2003年第1期30-33,60,共5页中德临床肿瘤学杂志（英文版）

摘　　要：Objective To investigate the value of the measurement of urinary hyaluronic acid (HA) levels for the diagnosis of bladder cancer and the possibility of replacing ELISA-like assay with radioimmunoassay to detect the levels of urinary HA. Methods Using the ELISA-like assay and radioimmunoassay at the same time to measure the HA levels in the urine specimens from 49 bladder cancer patients, 12 benign bladder tumor patients, 30 other genitourinary disease patients and 20 normal controls. Results There is not much difference between the consequences of the urinary HA levels whether we used the ELISA-like assay or radioimmunoassay to detect every specimen (P>0.05). When we used the results with radioimmunoassay for analysis, we found the levels of urinary HA of bladder cancer patients were 2–4 times than those of the benign bladder tumor patients, other genitourinary disease patients or normal individuals (P<0.01); With 137.5 ngHA/mg protein (113.6±23.9 ng/mg) as a minimum cutoff limit, this assay had a good sensitivity (91.8%) and specificity (91.9%) for the diagnosis of bladder cancer. Its difference in sensitivity meant a lot when compared with urine cytology (48.9%,P<0.01). Conclusion The urinary HA assay is a simple, convenient, noninvasive credible and cheap method with satisfactory sensitivity and specificity for the diagnosis of bladder carcinoma; radioimmunoassay is also a good means to measure the urinary HA levels. Key words Bladder carcinoma - Hyaluronic acid - Urine

关 键 词：Bladder carcinoma Hyaluronic acid URINE 

分 类 号：R737.14[医药卫生—肿瘤]