涎腺粘液表皮样癌癌胚抗原的免疫组化研究  

Immunohistochemical Study of Carcinoembryonic Antigen in Mucoepidermoid Carcinoma of Salivary Glands

作　　者：宋琦[1] 汪说之[2] 苏倩倩[2] 

机构地区：[1]遵义医学院口腔系 [2]湖北医学院附属口腔医院

出　　处：《华西口腔医学杂志》1992年第2期90-92,共3页West China Journal of Stomatology

摘　　要：采用癌胚抗原单克隆抗体,免疫组化 PAP 染色方法,对20例涎腺粘液表皮样癌进行了研究。结果显示:癌胚抗原阳性染色主要见于粘液细胞,表皮样细胞和中间细胞也有着色。根据染色强度和染色分布范围综合分析,4例高分化型肿瘤均呈癌胚抗原强阳性;5例中分化型肿瘤,4例弱阳性,1例阴性;11例低分化型肿瘤中有1例强阳性,1例弱阳性,9例阴性。经统计学分析,各型肿瘤之间癌胚抗原的表达均存在显著性差异。癌胚抗原可作为判断涎腺粘液表皮样癌不同分化程度的一个参考指标。Twenty cases of mucoepidermoid carcinoma of the salivary glands were studied by thePAP method with CEA monoclonal antibodies.In the tumor tissues,most of the mucuscells were clearly positive for CEA,some epidermoid and intermedial cells in the poorlyor moderately differentiated tumors were stained as well.The clear cells were alwaysnegative.All 4 well differentiated tumors showed strongly positive for CEA.Of 5 moder-ately differentiated tumors,4 were weakly positive,1 was negative.Of 11 poorly differ-entiated tumors,1 was strongly stained,1 was weakly stained,9 stained negatively.In concluaion,the expression of CEA in this tumor varied significantly and CEA mightbe a marker for identifying the degree of the differentiation of mucoepidermoid carcinomaof the salivary glands.

关 键 词：癌胚抗原 涎腺肿瘤 免疫组化 

分 类 号：R739.870.3[医药卫生—肿瘤]