藻酸双酯钠对脑血栓形成患者血液触变特性的影响  

Effect of Poly--saccharide Sulphate on Thixotropic Properties of Whole Blood in Patients with Cerebral Thrombosis

作　　者：周东[1] 杨怡静[2] 李良[2] 袁光固[1] 陈槐卿[2] 

机构地区：[1]华西医大神经病学教研室 [2]华西医大生物医学工程研究室

出　　处：《华西医科大学学报》1992年第3期241-244,共4页Journal of West China University of Medical Sciences

基　　金：国家自然科学基金~~

摘　　要：利用Low shear-30流变测定仪测定了30例男性脑血栓形成(CTh)患者的全血触变参数,结果显示血浆粘度(η_p)、屈服应力(τ_0)及粘度的非牛顿分量(η_s-μ)明显高于30例男性健康对照组。将患者随机分为二组(各15例),用双盲法分别以藻酸双酯钠(PSS)和低分子右旋糖酐(DX_(40))静脉滴注治疗两周,结果PSS组τ_0、(η_S-μ)和结构参数平衡值(A)明显下降,DX_(40)组的血液触变参数无明显改变,PSS组的临床疗效明显优于DX_(40)组,上述结果表明CTh患者的红细胞聚集明显增多,PSS对红细胞叠连的解聚作用DX_(40)的作用更明显。作者认为这是PSS治疗CTh的临床疗效优于DX_(40)的原因之一;作者提出血液触变参数可作为评定药物疗效的客观指标。Using Low shear 30 rheometer,we measured the thixotropic perameters ofblood from 30 patients suffering from ce-rebral thrombosis.The result showed that the yield stress(τ_0), non-Newtonian contri-bution of viscosity (η_s-μ) and viscosity ofplasma(ηp)were significantly higher thanthose in the control group. Those patientswere randomly divided into two groups.Each group included 15 patients. The pa-tients in group 1 and group 2 were treatedwith poly-saccharide sulphate(PSS) andDX_(40) respectively by Intravenous drip for14 days. The results showed tha τ_0, A, (η_s-μ)weresignificant decresed in group 1 after treat-ment,but no significantly change in thethixotropic parameters was found in group2 after treatment. The total curative ratein group 1 was higher than that in group 2.These results suggest that the patients withcerebral thrombosis had evidently increaseddegree of RBC aggregation. PSS could de-crease the aggregation of RBC more signi-ficantly then DX_(40) did.It was probably oneof the reasons why the therapeutic effectof PSS on cerebral thrombosis was betterthan that of DX_(40).

关 键 词：藻酸双酯钠 脑栓塞 

分 类 号：R743.33[医药卫生—神经病学与精神病学]