复方苄丝肼治疗儿童弱视的临床分析  

CLINICAL ANALYSIS OF MADOPA FOR TREATMENT OF CHILDHOOD AMBLYOPIA

作　　者：黄涵[1] 丘少杰[1] 

机构地区：[1]广东省惠州市中心人民医院眼科

出　　处：《中国煤炭工业医学杂志》2003年第6期555-556,共2页Chinese Journal of Coal Industry Medicine

摘　　要：目的　探讨复方苄丝肼 (美多巴 )治疗儿童弱视的临床疗效。方法　 60例弱视患者随机分为 2组 :观察组 :30例 (46眼 ) ,男 1 9例 (2 6眼 ) ,女 1 1例 (2 0眼 ) ;年龄 4～ 1 1岁 ,平均 (6 .67± 1 .89)岁 ;对照组 :30例 (49眼 ) ,男 1 4例 (2 4眼 ) ,女 1 6例 (2 5眼 ) ;年龄 4 .5～1 1岁 ,平均 (6 .73± 2 .0 2 )岁 ;全部患者均采用双盲法按体重给药 ,观察组 :美多巴 1 .0mg/kg;对照组 :维生素C 1 .0mg/kg。 3/d ,饭后口服 ,同时戴镜加遮盖治疗。用药前、用药后 1月定期检查视力 :采用国际标准视力表 ;服完药后每 6周 1次 ,持续 1年。结果　观察组 :46例弱视眼中 ,视力平均提高 (1 .69± 1 .0 4 )行 ,基本治愈率达 1 9.5 % ;进步 43 .5 % ,无效 37.0 %。对照组 :49例弱视眼中 ,基本治愈率为 1 0 .2 % ,进步 34 .7% ,无效 55 .1 %。二组各自用药后较用药前视力改善差异有显著性 ;服药后二组视力改善及疗效比较经统计学处理差异有显著性。观察组停药后随访 6～ 2 5个月 ,1 6眼 (34 .8% )视力继续改善 ;1 9眼 (41 .3 % )视力保持不变 ;1 1眼 (2 3 .9% )视力回退 :平均回退 (1 .72± 0 .66)行。结论　复方苄丝肼治疗儿童弱视临床效果好 ,副作用小。Objective To evaluate the efficacy of madopa (1.0mg/kg) for treatment of children amblyopia between the ages of 4 and 11 years. Methods 60 (95 eyes) patients were randomized divided into two group: A and B. madopa (1.0mg/kg) was given to group A and vitmin C (1.0mg/kg) was given to group B. Both group were combined with occlusion. Visual acuity was measured at baseline and 1 month during treatment. Results At 1 month, visual acuity of 63% eyes in group A and 44.9% in group B were improved (P<0.05 ). The basic cure rate was 19.5% in group A and 10.2% in group B (P<0.05). Mild side effect was only found in 2 cases of group A. Conclusion Average dose 1.0mg/kg of madopa was found to be well tolerated and efficacious for the treatment of childhood amblyopia.

关 键 词：弱视 儿童 复方苄丝肼 治疗 临床分析 疗效 美多巴 

分 类 号：R777.44[医药卫生—眼科]