急性脑血管病患者血清及脑脊液髓鞘碱性蛋白的测定及临床意义  

Radioimmunoassay of Serum and CSF Myelin Basic Protein and Its Application to Patients with Acute Cerebrovascular Accident

作　　者：周莉[1] 胡昌恒 袁光固[1] 徐文桢[1] 陈俊杰[2] 赖立辉[2] 

机构地区：[1]华西医大神经病学教研室 [2]华西医大生物化学教研室

出　　处：《华西医科大学学报》1992年第4期362-366,共5页Journal of West China University of Medical Sciences

基　　金：四川省科委资助课题;纽约中华医学基金

摘　　要：作者采用双抗体放射免疫测定法对34例急性脑血管病(CVD)、30例脱髓鞘疾病(DMD)及26例其他神经系统疾病(OND)患者的血清和脑脊液的髓鞘碱性蛋白(MBP)进行了测定。结果表明,急性CVD患者血清MBP平均含量及阳性率明显高于DMD与0ND的患者,差别有显著性(P<0.06).在脑脊液(CSF)标本中,急性CVD与DMD患者的MBP含量均明显升高,与OND患者比较均有显著性差异(P<0.05)。相关分析显示:急性CVD患者脑脊液和血清中MBP的含量之间呈正直线相关(r=0.72,P<0.01)。血清MBP含量与急性CVD的严重程度、意识障碍和肢体瘫痪的程度、CT扫描显示的脑损害程度和部位呈一致性。Myelin basic protein (MBP)was measured in the serum and CSF ofpetients with acute cerebrovascular disease(CVD,34 cases), demyelinating disorders(DMD,30 cases) and other neurologicaldiseases (OND,26 cases) by using a doubleantibody radioimmunoassay (RIA).Patientswith acute CVD had a mean serum MBP con-centration and positivity rate much higherthan those with DMD and OND. The dif-ferences were significant (P<0. 05). InCSF. MBP levels in patients with acuteCVD and petients with DMD were signifi-cantly greater than those in OND patients(P<0. 05).The results also show that therewas a linear relationship between the CSFMBP levels and the serum MBP levels inpatients with acute CVD(r = 0. 72, P<0. 01),but no such relationship in patients withDMD and OND.The amount of serum MBPwas also significantly correlated to theseverity of acute CVD,to the level of con-sciousness disorder and limb paralysis,andto the extent and site of the cerebral le-sion at CT-scan (P<0. 05).This study showsthat the measurement of brain specific MBPin serum as a marker of cerebral damagemay have clinical value in the diagnosisand prognosis of patients with CVD.

关 键 词：脑血管疾病 髓鞘碱性蛋白 测定 

分 类 号：R743.04[医药卫生—神经病学与精神病学]