贲门癌组织微粒体环氧化物羟化酶基因多态变化  

Polymorphism of mEH in gastric cardia carcinogenesis

作　　者：周琦[1] 郑作昱[1] 王立东[1] 范宗民[1] 郭花芹[1] 高社干[1] 秦艳茹[1] 安继业[1] 贺新伟[1] 王启鸣[1] 王道存[1] 李吉林 刘宾[3] 

机构地区：[1]郑州大学医学院癌症研究室,郑州450052 [2]林州市姚村食管癌医院病理科,林州456592 [3]首都医科大学同仁医院消化内科,北京100013

出　　处：《郑州大学学报（医学版）》2003年第3期321-323,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：国家杰出青年科学基金3 0 0 2 5 0 16;河南省高校创新人才工程基金;河南省医药卫生创新人才工程基金;国家自然科学基金资助项目39770296

摘　　要：目的 :探讨贲门癌组织微粒体环氧化物羟化酶 (mEH)基因多态性改变 ,进一步深入了解贲门癌高易感性分子基础。方法 :利用PCR和PCR SSCP方法对 19例贲门腺癌和 72例正常对照组织mEH基因多态性进行了检测。结果 :贲门腺癌和正常对照组织中 ,mEH的Arg/His和His/His基因型合并在一起分别占 16 %和 15 % ,His等位基因对贲门癌易感性并无明显影响 (OR =0 .72 ) ;mEH的His/Tyr和Tyr/Tyr基因型合并在一起分别占 5 8%和 5 7% ,Tyr等位基因并未影响个体对贲门癌的易感性 (OR =0 .92 )。结论 :mEH基因多态对贲门癌易感性无明显影响。Aim: To understand the molecular basis for high susceptibility of gastric cardia carcinoma(GCA) in Linzhou, susceptibility of mEH in GCA was determined. Methods: PCR, PCR RFLP were used to determine the polymorphisms of metabolizing enzymes mEH on 19 GCA samples and 72 normal controls. Results: The combined frequencies of the Arg/His and His/His genotype of mEH in GCA and normal controls were 16% and 15%, respectively. The combined frequencies of His/Tyr and Tyr/Tyr genotype of mEH in GCA and normal controls were 58% and 57%, respectively. Both

关 键 词：贲门癌 微粒体环氧化物羟化酶 基因多态 癌组织 

分 类 号：R735.1[医药卫生—肿瘤]