湖南汉族人群HLA-DP、-DQ位点等位基因多态性与鼻咽癌的相关性  

Association study on HLA-DP and-DQ allelic polymorphisms and nasopharyngeal carcinoma in the Han nationality in Hunan province

作　　者：周劲峰[1] 郭实士[1] 余平[1] 

机构地区：[1]中南大学湘雅医学院免疫学研究室,长沙410078

出　　处：《中华医学遗传学杂志》2003年第3期262-264,共3页Chinese Journal of Medical Genetics

基　　金：国家自然科学基金 (392 70 66);CMB基金~~

摘　　要：目的　探讨湖南汉族人群 HL A- DP、HL A- DQ位点等位基因多态性与鼻咽癌遗传易感性之间的关系。方法　应用聚合酶链反应 -特异性寡核苷酸探针基因分型技术对 87例湖南汉族鼻咽癌患者与91名健康对照作 HL A- DPA1、- DPB1、- DQA1及 - DQB1的基因分型 ,采用 χ2检验比较两组各位点等位基因频率 ,单倍型频率分布的差异。结果　发现鼻咽癌组 DPA1* 0 2 0 1、DPB1* 190 1、DQA1* 0 2 0 1较对照组明显降低 ,DPB1* 0 4 0 2、DQA1* 0 10 1较对照组明显升高 ;单倍型 DPA1* 0 2 0 1- DPB1* 14 0 1及 DQA1*0 2 0 1- DQB1* 0 2 0 1较对照明显降低 ;但 P值经 Bonferroni校正后 ,差异均无显著性 ( Pc>0 .0 5 )。结论　湖南汉族人群 HL A- DP和 - DQ位点与鼻咽癌无明显相关 ,与以往用受累同胞对方法在鼻咽癌家系中未能证实鼻咽癌易感基因与 HL A- DP和 -Objective: To investigate whether the polymorphisms of HLA-DPA1,DPB1,DQA1 and DQB1 alleles were associated with nasopharyngeal carcinoma (NPC). Methods: Eighty-seven NPC patients and 91 normal controls of Han nationality in Hunan province were genotyped for HLA-DPA1,HLA-DPB1, HLA-DQA1 and HLA-DQB1 by PCR/SSO technique. Results: The frequencies of allelic gene DPA1 * 0201,DPB1 * 1901 and DQA1 * 0201 were lower, and of DPB1 * 0402, DQA1 * 0101 were higher in patients than in controls; the frequencies of haplotype DPA1 * 0201-DPB1 * 1401 and DQA1 * 0201-DQB1 * 0201 in patients were lower than those in controls; however, the values of P are not significant after Bonferroni correction (Pc>0.05). Conclusion: No significant association between the HLA-DP and HLA-DQ loci and NPC in Han nationality in Hunan province was confirmed.

关 键 词：湖南 汉族人群 HLA-DP HLA-DQ位点 等位基因多态性 鼻咽癌 遗传易感性 

分 类 号：R739.65[医药卫生—肿瘤]