红细胞天然免疫分子CD59与可溶性IL-2R相关性分析  

Analysis on the Association between CD59 on Erythrocytes and Soluble IL-2R

作　　者：郭峰[1] 钱宝华[1] 花美仙[1] 张乐之[2] 许育[2] 张军[2] 刘辉[3] 薛春燕[4] 

机构地区：[1]第二军医大学长海医院输血科血液免疫研究室,上海200433 [2]第二军医大学长海医院实验诊断科,上海200433 [3]第二军医大学长海医院皮肤科,上海200433 [4]第二军医大学长海医院肿瘤科,上海200433

出　　处：《上海免疫学杂志》2003年第3期208-209,共2页Shanghai Journal of Immunology

摘　　要：为了探讨红细胞CD5 9与可溶性IL 2受体 (sIL 2R )之间变化规律。采用流式细胞仪测定红细胞CD5 9,用ELISA法测定sIL 2R含量。结果发现肿瘤患者红细胞CD5 9数量 (平均荧光相对强度 5 2 5 8± 12 4 2 )明显低于 2 6例银屑病患者 ( 6 31 0 0±16 6 70 ,P <0 0 5 ) ,而 19例正常人sIL 2R含量 ( 1736 5 8± 6 5 0 10 )ng/L明显低于肿瘤患者 ( 2 36 4 80± 831 2 0 ,P <0 0 5 ) ,6 5例标本同时测定红细胞CD5 9和sIL 2R ,两者之间存在负相关 (r= 0 312 ,P <0 0 5 )。红细胞CD5 9与sILTo observe the association between CD59 on erythrocytes and soluble IL 2R (sIL 2R),the expression of CD59 on erythrocytes was determined by flow cytometery analysis,and the content of sIL 2R determined by ELISA It was found that the amount of CD59 on erythrocytes in patients with tumors was significantly lower than those of 26 patients with psoriasis,and the contents of sIL 2R of 19 normal adults were significantly lower than those of patients with tumors Negative correlation existed between CD59 on erythrocytes and sIL 2R in 85 cases of testing These results support useful information to the studies of immunoregulation and have potential significance for the clinicians

关 键 词：红细胞CD59 可溶性IL-2受体 血小板CD69 肿瘤 银屑病 

分 类 号：R730.3[医药卫生—肿瘤]